2011
DOI: 10.1016/j.neulet.2011.02.024
|View full text |Cite
|
Sign up to set email alerts
|

Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
16
1

Year Published

2012
2012
2024
2024

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 33 publications
(17 citation statements)
references
References 26 publications
0
16
1
Order By: Relevance
“…A VBM study of neuroanatomy in 40 schizophrenia patients targeted rs2396753, a SNP that had been previously associated with auditory hallucinations (Sanjuán et al, 2006), and reported that the C allele was correlated with reductions in gray matter volume in the dorsolateral prefrontal cortex (dlPFC) (Španiel et al, 2011). Another study in 293 schizophrenia patients suggested that a different SNP, rs2253478, was associated with poverty of speech in schizophrenia, but the relevance of this polymorphism for neuroanatomy was not investigated (Tolosa et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…A VBM study of neuroanatomy in 40 schizophrenia patients targeted rs2396753, a SNP that had been previously associated with auditory hallucinations (Sanjuán et al, 2006), and reported that the C allele was correlated with reductions in gray matter volume in the dorsolateral prefrontal cortex (dlPFC) (Španiel et al, 2011). Another study in 293 schizophrenia patients suggested that a different SNP, rs2253478, was associated with poverty of speech in schizophrenia, but the relevance of this polymorphism for neuroanatomy was not investigated (Tolosa et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Subsequent studies identifi ed additional functional mutations which cause similar defi cits in other cases, providing further compelling FOXP2 and three psychiatric disorders 147 sound disorder in Chinese subjects (150 patients with speech sound disorder diagnosed according to DSM-IV and 140 controls) (Zhao et al 2010). Recently, a study showed that the common SNP rs2396753 had signifi cant effects on grey matter concentration in patients with schizophrenia (Spaniel et al 2011). However, some other studies did not fi nd signifi cant association between FoxP2 and mental disorders (Newbury et al 2002;Marui et al 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The Fox family has diverse functions throughout the body, and certain isoforms have been previously associated with mental illness. A study by Spaniel and colleagues 48 investigated the potential link between FOXP2 -a Fox family gene previously associated with the development of speech and language -and schizophrenia, hypothesizing a connection between Fox-P2 and schizophrenia owing to the underlying deficits in language processing inherent to the disease. 48 These investigators identified reductions in grey matter concentrations in patients with schizophrenia carrying the C risk allele of rs2396753 (FOXP2); however, the clinical presentation of the disease, as measured by the Positive And Negative Syndrome Scale (PANSS), did not differ between genotype groups.…”
Section: J Psychiatry Neurosci 2017;42(3)mentioning
confidence: 99%