Genetic variation in bitter taste receptor gene TAS2R38 , PROP taster status and their association with body mass index and food preferences in Indian population

Deshaware, Shweta

doi:10.1016/j.gene.2017.06.047

Cited by 42 publications

(38 citation statements)

References 66 publications

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“…According to the in vitro assays of Buffet et al (2005) rs713598 has the greatest effect on bitter taste signal transduction, rs1726866 possesses weaker effects, and rs10246939 site has no detectable effect at all (Bufe et al, 2005). The bitter taste modality has been the most extensively studied and the majority of genetic association studies related to the bitter quality focused on TAS2R38 gene polymorphisms (Kim et al, 2003;Mennella et al, 2005;Sandell and Breslin, 2006;Sacerdote et al, 2007;Timpson et al, 2007;Duffy et al, 2010;Ooi et al, 2010;Wooding et al, 2010;Calò C et al, 2011;Feeney et al, 2011;Gorovic N et al, 2011;Lucock et al, 2011;Mennella et al, 2011a;Cabras et al, 2012;Campbell et al, 2012;Colares-Bento et al, 2012;Negri et al, 2012;Behrens et al, 2013;Inoue et al, 2013;Laaksonen et al, 2013;Melis et al, 2013;Bering et al, 2014;Garneau et al, 2014;Keller et al, 2014;Ledda et al, 2014;Mennella et al, 2014a;Robino et al, 2014;Melis et al, 2015;Nolden et al, 2016;Robino et al, 2016;Bella et al, 2017;Carrai et al, 2017;Deshaware and Singhal, 2017;Feeney et al, 2017;Risso ...…”

Section: Discussionmentioning

confidence: 99%

“…The number of studies investigating salty Dias et al, 2013;Rawal et al, 2013;Feeney and Hayes, 2014;Deshaware and Singhal, 2017), umami (Raliou et al, 2009;Shigemura et al, 2009;Chen et al, 2009;Risso et al, 2017), and sour Laaksonen et al, 2013;Rawal et al, 2013;Carrai et al, 2017) taste preferences was limited. The effect of these latter two taste modalities on health status is not yet known.…”

Section: Discussionmentioning

confidence: 99%

“…Homozygotes of TRPV1 rs8065080 (CC genotype), SCNN1B rs239345 (AA genotype), and rs3737665 (TT genotype) perceived salt solutions as significantly weaker than heterozygotes or other allele homozygotes (Dias et al, 2013). Other findings were related to genes linked to bitter (TAS2R38, CA6) Feeney and Hayes, 2014;Deshaware and Singhal, 2017) and umami taste responsiveness (TAS1R1) (Rawal et al, 2013). Future studies are essential to confirm these findings and analyze the role of receptors involved in other taste perception pathways rather than salt.…”

Section: Salty Taste Preferencementioning

confidence: 93%

“…Associated with PROP phenotype (Timpson et al, 2007;Bering et al, 2014) 0 - (Kim et al, 2003;Duffy et al, 2004a;Mennella et al, 2005;Sandell and Breslin, 2006;Duffy et al, 2010;Wooding et al, 2010;Calò C et al, 2011;Lucock et al, 2011;Cabras et al, 2012;Negri et al, 2012;Campbell et al, 2012;Melis et al, 2013;Allen et al, 2014;Bering et al, 2014;Garneau et al, 2014;Robino et al, 2014;Melis et al, 2015;Nolden et al, 2016;Bella et al, 2017;Deshaware and Singhal, 2017;Risso et al, 2017 in children also, Behrens et al, 2013) 2 (Feeney et al, 2017)…”

Section: Bitter Taste Preferencementioning

confidence: 99%

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Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review

2019

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Background: The rise in nutrition-related morbidity and mortality requires public health intervention programs targeting nutritional behavior. In addition to socio-economical, socio-cultural, psychological determinants, taste is one of the main factors that influence food choices. Differences in taste perception and sensitivity may be explained by genetic variations, therefore the knowledge of the extent to which genetic factors influence the development of individual taste preferences and eating patterns is important for public policy actions addressing nutritional behaviors. Our aim was to review genetic polymorphisms accounting for variability in taste and food preferences to contribute to an improved understanding of development of taste and food preferences. Methods: The electronic databases PubMed, Scopus, and Web of Science were searched using MeSH in PubMed and free text terms for articles published between January 1, 2000 and April 13, 2018. The search strategy was conducted following the PRISMA statement. The quality of the included studies was assessed by the validated Q-Genie tool. Results: Following the PRISMA flowchart, finally 103 articles were included in the review. Among the reviewed studies, 43 were rated to have good quality, 47 were rated to have moderate quality, and 13 were rated to have low quality. The majority of the studies assessed the association of genetic variants with the bitter taste modality, followed by articles analyzing the impact of polymorphisms on sweet and fat preferences. The number of studies investigating the association between umami, salty, and sour taste qualities and genetic polymorphisms was limited. Conclusions: Our findings suggest that a significant association exists between TAS2R38 variants (rs713598, rs1726866, rs10246939) and bitter and sweet taste preference. Other confirmed results are related to rs1761667 (CD36) and fat taste responsiveness. Otherwise further research is essential to confirm results of studies related to genetic variants and individual taste sensitivity. This knowledge may enhance our understanding

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Salty Taste Preferencementioning

confidence: 93%

Section: Bitter Taste Preferencementioning

confidence: 99%

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Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review

2019

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“…This conclusion may be based, in part, on data showing that at high NaCl concentrations (>0.35 M), NaCl ratings are not independent of PROP taster status and diverge in super tasters [ 41 ]. Nevertheless, the use of NaCl as a reference standard has been successfully employed by numerous laboratories across the globe [ 17 , 18 , 27 , 33 , 34 , 38 , 39 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Data described later in this review illustrate this point.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Phenotypic Characterization of the Oral Marker, PROP

et al. 2017

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In the last several decades, the genetic ability to taste the bitter compound, 6-n-propyltiouracil (PROP) has attracted considerable attention as a model for understanding individual differences in taste perception, and as an oral marker for food preferences and eating behavior that ultimately impacts nutritional status and health. However, some studies do not support this role. This review describes common factors that can influence the characterization of this phenotype including: (1) changes in taste sensitivity with increasing age; (2) gender differences in taste perception; and (3) effects of smoking and obesity. We suggest that attention to these factors during PROP screening could strengthen the associations between this phenotype and a variety of health outcomes ranging from variation in body composition to oral health and cancer risk.

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Taste receptors in chronic rhinosinusitus, what is the evidence? A systematic review

Chen

Song

Hura

et al. 2022

Int Forum Allergy Rhinol

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Background Bitter and sweet taste receptors (T2Rs and T1Rs), respectively, are involved in the innate immune response of the sinonasal cavity and associated with chronic rhinosinusitis (CRS). Growing evidence suggests extraoral TRs as relevant biomarkers, but the current understanding is incomplete. This systematic review synthesizes current evidence of extraoral taste receptors in CRS. Methods PubMed, Embase, Cochrane, Web of Science, and Scopus were reviewed in accordance with Preferred Reporting Items for Systemic Reviews and Meta‐Analyses guidelines and included studies of genotypic and phenotypic T2R/T1R status in CRS patients. Results Twenty‐two studies with 3845 patients were included. Seventeen studies evaluated genotype and 10 evaluated taste phenotypes. Four of 6 studies examining the haplotype distribution of the T2R, TAS2R38, demonstrated increased AVI/AVI haplotype (“nontaster”) frequency in CRS. Meanwhile, 2 studies demonstrated decreased bitter sensitivity in CRS with nasal polyposis (CRSwNP), whereas 3 other studies reported decreased bitter sensitivity only in CRS without nasal polyposis (CRSsNP). Findings regarding sweet sensitivity were mixed. Three studies with cystic fibrosis patients (n = 1393) were included. Studies investigating the association between clinical outcomes and TAS2R38 alleles were limited, but the nonfunctional combination of AVI/AVI was associated with increased utilization of sinus surgery and, in CRSsNP patients, with poorer improvement of symptoms postoperatively. Conclusion Both genotypic and phenotypic assessments of T2Rs suggest a potential association with CRS, particularly CRSsNP. However, limited evidence and mixed conclusions cloud the role of T2Rs in CRS. Future investigations should aim to increase diverse populations, broaden institutional diversity, examine T1Rs, and utilize uniform assessments.

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Genetic variation in bitter taste receptor gene TAS2R38 , PROP taster status and their association with body mass index and food preferences in Indian population

Cited by 42 publications

References 66 publications

Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review

Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review

Factors Influencing the Phenotypic Characterization of the Oral Marker, PROP

Taste receptors in chronic rhinosinusitus, what is the evidence? A systematic review

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