Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population

Shen, Huanxi; Dou, Jianrui; Han, Lei; Bai, Ying; Li, Qian; Hong, Zhi-Qiang; Shi, Jianzhong; Zhang, Hengdong; Zhang, Feng; Du, Chung-Li; Tong, Zhimin; Zhu, Baoli

doi:10.1007/s00420-015-1100-8

Cited by 15 publications

(8 citation statements)

References 43 publications

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“…Compared with workers who did not carry dangerous genotypes and were exposed to CNE ≤ 92 [dB(A)·Year], workers carried dangerous genotypes and CNE > 92 [dB(A)·Year] had a significantly increased risk of NIHL. This phenomenon may be due to the fact that people exposed to noise are more susceptible to NIHL under strong noise levels 28 . These findings suggest that gene-environment interaction may play an important role in the risk of NIHL.…”

Section: Discussionmentioning

confidence: 99%

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Ruan

Zhang

Mai

et al. 2021

Sci Rep

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Genetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.

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Section: Discussionmentioning

confidence: 99%

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Ruan

Zhang

Mai

et al. 2021

Sci Rep

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“…We found that workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of developing NIHL compared to workers without them (OR = 5.468, 95% CI = 1.057-28.295). This phenomenon may be due to the fact that noise-exposed persons are more susceptible to NIHL at high noise levels [24].…”

Section: Agena Massarray System Genotyping Stepsmentioning

confidence: 99%

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Ruan

Zhang

Mai

et al. 2020

Preprint

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Background: Genetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). This study explored the relationship between the SNP of CASP genes and the NIHL susceptibility of Chinese workers exposed to occupational noise.Methods: 191 cases and 191 controls were selected by 1:1 case control study. Among them, case groups were screened from workers exposed to noise at binaural high-frequency hearing thresholds greater than 25 dB (A). The control group selected workers with hearing thresholds≤25 dB (A) in any binaural frequency band based on matching factors such as age, exposure time to noise, and operating position. The blood samples of two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction - ligase detection reaction method. Conditional logistic regression correction was used to analyze genetic variation associated with susceptibility to NIHL. Odds Ratios (OR) and 95% confidence intervals (CI) were calculated.Results: There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL (OR = 0.453, 95% CI = 0.241 ~ 0.852). Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL (OR = 0.458, 95% CI = 0.243 ~ 0.862). Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype (OR = 1.839, 95% CI = 1.033 ~ 3.274). The CASP7 gene interacted with factors such as age, smoking status, dietary taste, and conscious auditory system symptoms on the risk of NIHL (P <0.05).Conclusions: The single nucleotide polymorphism of CASP7 gene interacts with factors such as age, frequency of smoking, dietary taste, and conscious auditory system symptoms on the risk of NIHL.

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“…Кроме этого, H. Shen и соавт. [56] выявили ассоциацию развития тугоухости при воздействии шума с наличием полиморфизма (-656T>G) в гене, кодирующем другой фермент репарации -апуриновую/апиримидиновую эндонуклеазу. Также было показано, что для китайской популяции наличие мутаций в обоих этих генах значительно увеличивает риск развития заболевания.…”

Section: другие гены предрасположенности к тугоухости индуцированнойunclassified

“…Аналогичное исследование этих же полиморфизмов провели А. Konings и соавт. [52] Китай (613/613) [56] цируемой шумом потерей слуха для китайской популяции, но являются редкими или отсутствуют в европейских популяциях, не исключает наличие ассоциации однонуклеотидных замен в генах белков теплового шока с восприимчивостью к шуму и может объясняться этническими различиями.…”

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The genetic aspects of occupational hearing impairment

Krasitskaya

Bashmakova

Dobretsov

et al. 2017

Vestn. otorinolaringol.

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This article was designed to be the overview of the current literature publications concerning the identification of the genetic markers of susceptibility to the noise-induced loss of hearing. The analysis of these data has demonstrated that the major gene polymorphisms associated with the development of this pathological condition are localized in the genes encoding for the antioxidant systems, potassium homeostasis, and adhesion molecules as well as in the genes involved in intercellular coupling, the mechanisms underlying the cellular response to stress, activation and regulation of heat shock proteins, and signaling function of the immune system. It is concluded that the further investigations into the genetic aspects of the full-genome sequencing techniques and the search for genomic associations could greatly contribute to the development of personalized medicine and the reduction of risks of occupational noise-induced sensorineural impairment of hearing.

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Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population

Abstract: Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.

Cited by 15 publications

References 43 publications

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

The genetic aspects of occupational hearing impairment

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