Genetic Variation in Alcohol Dehydrogenase and the Beneficial Effect of Moderate Alcohol Consumption on Myocardial Infarction

Lm, Hines; Mj, Stampfer; Ma, Jing; Jm, Gaziano; Pm, Ridker; Hankinson, SE; Sacks, Frank M.; Eb, Rimm; Hunter, D.J.

doi:10.1056/nejm200102223440802

Cited by 271 publications

(193 citation statements)

References 24 publications

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“…30 Average daily alcohol consumption was calculated on the basis of the amount and frequency of consumption.…”

Section: Documentation Of Alcohol Consumptionmentioning

confidence: 99%

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

Chen

et al. 2009

Hypertens Res

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The prevalence of type II diabetes mellitus (T2DM) in coronary artery disease (CAD) patients has been steadily increasing, especially in East Asian countries. Although many studies have suggested that certain genetic variants may predispose to the development of T2DM, very few studies investigated the genetic link with T2DM in CAD patients of East Asia. In this study, we investigated the relationship between Glu504Lys polymorphism in the acetaldehyde dehydrogenase 2 (ALDH2) gene, a key enzyme of alcohol metabolism, and the risk of having T2DM in Chinese Han CAD patients. We enrolled 542 CAD patients (180 women and 362 men) and 309 CADÀ/DMÀ subjects (152 women and 157 men). T2DM was confirmed in 47.4% of CAD patients. Logistic and linear regression analyses showed that ALDH2 mutant genotypes (*1/*2 and *2/*2) were an independent risk factor for both T2DM in female CAD patients, even after controlling for alcohol consumption (OR¼1.95, P¼0.043), and fasting plasma glucose (FPG) in CADÀ/DMÀ women (P¼0.015), whereas the association with FPG disappeared after controlling for high-sensitivity C-reactive protein, a classic inflammatory biomarker. However, there was no relationship between the ALDH2 genetic polymorphism and T2DM or FPG in men. These findings suggest that the ALDH2 polymorphism is associated with an increased risk of T2DM in female CAD patients, and this association could be causal on the basis of the association between the polymorphism and FPG, which is partly explained by an increased inflammatory status. These findings will benefit the screening and treatment of a high-risk population in East Asians.

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“…30 Average daily alcohol consumption was calculated on the basis of the amount and frequency of consumption.…”

Section: Documentation Of Alcohol Consumptionmentioning

confidence: 99%

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

Chen

et al. 2009

Hypertens Res

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“…However, few studies have examined the influence of candidate genes that regulate alcohol metabolism on the association between moderate drinking and health. Previous reports suggest that the alcohol dehydrogenase 1C (ADH1C) gene may influence the association between alcohol consumption and MI [28,29], but no previous study has assessed genetic influences on the association between alcohol consumption and HF. Understanding genetic modifiers of the relation between alcohol consumption and HF is important because a subset of genetic variations may identify a group of the population that is more likely to benefit from moderate drinking.…”

Section: Drinking Patterns and Other Modifiers Of The Association Betmentioning

confidence: 99%

Alcohol consumption and heart failure: A systematic review

Djoussé

Gaziano²

2008

Curr Atheroscler Rep

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115

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Heart failure (HF) remains a major public health issue. It is estimated that about 500,000 Americans per year are diagnosed with HF. Despite advanced medical and surgical treatments for HF, mortality after the onset of HF is still high, thereby underscoring the importance of primary prevention. Among modifiable lifestyle factors, alcohol consumption appears to play a role in the development of HF. Although excessive drinking has been known to lead to alcoholic cardiomyopathy and light-tomoderate drinking may confer some cardiovascular benefits, recent studies suggest it is not only the quantity, but also drinking patterns and genetic factors, that may influence the relation between alcohol consumption and cardiovascular disease. This article reviews current evidence on the association between alcohol consumption and HF.

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“…[14][15][16] Genetic studies support these mechanisms. 17 In spite of laboratory findings, most epidemiologic studies have failed to detect large differences in benefits between the various types of alcoholic beverages. 18,19 Some studies have reported a stronger protective effect for wine in their point estimates, [20][21][22][23][24] but, in general, there were no statistically significant differences.…”

Section: Introductionmentioning

confidence: 99%

Type of alcoholic beverage and first acute myocardial infarction: A case‐control study in a mediterranean country

Fernández-Jarne

Martínez-Losa

Serrano-Martínez

et al. 2003

Clinical Cardiology

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SummaryBackground: Although international comparisons have consistently found an inverse association between wine and coronary heart disease, few epidemiologic studies are available in Southern Europe. We assessed the association of wine, red wine, and the pattern of drinking wine during meals with the risk of myocardial infarction.Hypothesis: We specifically evaluated three hypotheses: (1) Is the protection against incidence of nonfatal myocardial infarction stronger for wine than for other alcoholic beverages? (2) Does the wine consumed during meals represent a more beneficial pattern of alcohol consumption? (3) Is red wine more advantageous than other types of wine?Methods: A case-control study (171 cases, 171 matched controls) was conducted in Spain. Multiple dietary and nondietary potential confounders were assessed.Results: Exposure to wine, red wine, and wine during meals was associated with risk reductions similar to those of other alcoholic beverages (point estimates of the odds ratio for low and high intake were 0.48 and 0.38 for wine; 0.42 and 0.55 for other beverages). However, after controlling for total alcohol intake, wine consumption (g/day) improved the prediction of a myocardial infarction.Conclusions: Our data showed that red wine or drinking wine during meals was similar to alcohol from other sources

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Genetic Variation in Alcohol Dehydrogenase and the Beneficial Effect of Moderate Alcohol Consumption on Myocardial Infarction

Abstract: Moderate drinkers who are homozygous for the slow-oxidizing ADH3 allele have higher HDL levels and a substantially decreased risk of myocardial infarction.

Cited by 271 publications

References 24 publications

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

Alcohol consumption and heart failure: A systematic review

Type of alcoholic beverage and first acute myocardial infarction: A case‐control study in a mediterranean country

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