Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population

Abstract

Phosphatidylinositol-specific phospholipase C X domain 3 (PLCXD3) has been shown to influence pancreatic β-cell function by disrupting insulin signaling. Herein, we investigated two genetic variants in the PLCXD3 gene in relation to type 2 diabetes (T2D) or metabolic syndrome (MetS) in the Emirati population. In total, 556 adult Emirati individuals (306 T2D and 256 controls) were genotyped for two PLCXD3 variants (rs319013 and rs9292806) using TaqMan genotyping assays. The frequency distribution of minor homozygous CC genotype of rs9292806 and GG genotype of rs319013 were significantly higher in subjects with MetS compared to Non-MetS (p < 0.01). The minor homozygous rs9292806-CC and rs319013-GG genotypes were significantly associated with increased risk of MetS (adj. OR 2.92; 95% CI 1.61–5.3; p < 0.001) (adj. OR 2.62; 95% CI 1.42–4.83; p = 0.002), respectively. However, no associations were detected with T2D. In healthy participants, the homozygous minor genotypes of both rs9292806 and rs319013 were significantly higher fasting glucose (adj. p < 0.005), HbA1c (adj. p < 0.005) and lower HDL-cholesterol (adj. p < 0.05) levels. Data from T2D Knowledge Portal database disclosed a nominal association of rs319013 and rs9292806 with T2D and components of MetS. Bioinformatics prediction analysis showed a deleterious effect of rs9292806 on the regulatory regions of PLCXD3. In conclusion, this study identifies rs319013 and rs9292806 variants of PLCXD3 as additional risk factors for MetS in the Emirati population.

Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis

“…Our search strategy ( Figure 1 and Methods section) identified 36 studies that met our inclusion criteria ( Bayoumi et al, 2007 ; Bayoumy et al, 2012 ; Boumaiza et al, 2012a ; Boumaiza et al, 2012b ; Ghattas et al, 2013 ; Mohamed Youssef et al, 2013 ; Zadjali et al, 2013 ; Ajjemami et al, 2014 ; Al-Daghri et al, 2014 ; Mackawy and Badawi, 2014 ; Youssef et al, 2014 ; Ajjemami et al, 2015 ; Mehanna et al, 2015 ; Alnory et al, 2016 ; Mehanna et al, 2016 ; Elouej et al, 2016a ; RaafatAbdRaboh et al, 2016 ; Elouej et al, 2016b ; Elouej et al, 2016c ; Khella et al, 2017 ; Hasan et al, 2017 ; Lakbakbi El Yaagoubi et al, 2017 ; Mackawy, 2017 ; Morjane et al, 2017 ; Ismail et al, 2019 ; Ibrahim and Bastawy, 2020 ; Salami and El Shamieh, 2019 ; ElGhareeb et al, 2019 ; Nizam et al, 2019 ; Boulenouar et al, 2019 ; Aljaibeji et al, 2020 ; Osman et al, 2020 ; Alenad et al, 2020 ; Hechmi et al, 2020 ; Kefi, 2021 ). In most cases, studies were excluded because they lacked detailed results, such as odds ratios, confidence intervals, and p -values.…”

Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and atherosclerosis

“…Taneera Jalal revealed and confirmed PLCXD3 as a potential regulator of pancreatic islet function ( 47 ). An Emiratis population-based cross-sectional study indicated that genetic variants of the PLCXD3 are correlated with lower HDL-cholesterol and MS risk ( 48 ). According to GO analysis, as previously described, PLCXD3 was closely related to the lipid catabolic process.…”

Table3.pdf

“…Our search strategy (Figure 1 and Methods section) identified 36 studies that met our inclusion criteria (Bayoumi et al, 2007;Bayoumy et al, 2012;Boumaiza et al, 2012a;Boumaiza et al, 2012b;Ghattas et al, 2013;Mohamed Youssef et al, 2013;Zadjali et al, 2013;Ajjemami et al, 2014;Al-Daghri et al, 2014;Mackawy and Badawi, 2014;Youssef et al, 2014;Ajjemami et al, 2015;Mehanna et al, 2015;Alnory et al, 2016;Mehanna et al, 2016;Elouej et al, 2016a;RaafatAbdRaboh et al, 2016;Elouej et al, 2016b;Elouej et al, 2016c;Khella et al, 2017;Hasan et al, 2017;Lakbakbi El Yaagoubi et al, 2017;Mackawy, 2017;Morjane et al, 2017;Ismail et al, 2019;Ibrahim and Bastawy, 2020;Salami and El Shamieh, 2019;ElGhareeb et al, 2019;Nizam et al, 2019;Boulenouar et al, 2019;Aljaibeji et al, 2020;Osman et al, 2020;Alenad et al, 2020;Hechmi et al, 2020;Kefi, 2021). In most cases, studies were excluded because they lacked detailed results, such as odds ratios, confidence intervals, and p-values.…”