Genetic Variants of <i>VDR</i> and <i>PGC-1α</i> Are Not Associated with the Risk of Endometriosis in Indian Women

Beeram, Himabindu; Siddamalla, Swapna; Tumu, Venkat Reddy; KV, Veena; Vidala, Akanksha; Deenadayal, Mamata; Shivaji, Sisinthy; Bhanoori, Manjula

doi:10.1089/dna.2022.0350

Cited by 1 publication

(1 citation statement)

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“…The distribution of the PPAR-γ2 Pro12Ala polymorphism differed between the advanced-stage endometriosis group and the control group, while the frequency for the Ala-12 allele variant was significantly higher in the control group than in patients with advanced endometriosis stages ( 55 ). Last but not least, Beeram et al reported that genetic variants of the PPARγ coactivator 1α (PGC-1α) do not seem to correlate with the risk of endometriosis in the Indian population, with GTT of PGC-1α gene constituting the most common haplotype in Indian women ( 56 ).…”

Section: The Role Of Ppars In the Pathogenesis Of Endometriosismentioning

confidence: 99%

The role of peroxisome proliferator-activated receptors in endometriosis

Psilopatis,

Theocharis,

Beckmann

2024

Front. Med.

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Endometriosis constitutes the most common cause of chronic pelvic pain in female patients and is associated with infertility. Although there is no known cause for the disease, it is a heritable condition that is determined by numerous genetic, epigenetic, and environmental aspects. Peroxisome proliferator-activated receptors (PPARs) represent nuclear receptor proteins that control gene expression. By using the MEDLINE and LIVIVO databases we conducted a literature review in order to look into the role of PPARs in the endometriosis pathophysiology and succeeded in revealing 36 pertinent publications between 2001 and 2022. In regards to PPAR expression in endometriosis, PPARγ seems to represent the most studied PPAR isoform in endometriosis and to influence various pathways involved in the disease onset and progression. It's interesting to note that diverse treatment agents targeting the PPAR system have been identified as innovative, effective therapeutic alternatives in the context of endometriosis treatment. In conclusion, PPARs appear to contribute an important role in both endometriosis pathophysiology and therapy.

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Section: The Role Of Ppars In the Pathogenesis Of Endometriosismentioning

confidence: 99%