Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Wang, Meng; Hughes, Anne E.; Patterson, Chris; Belton, Christine; Kamaruddin, Muhammad S.; Horan, Paul; Kee, Frank; McKeown, Pascal

doi:10.1186/1471-2350-8-62

Cited by 12 publications

(9 citation statements)

References 23 publications

(30 reference statements)

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“…[23]2007GermanyCaucasians11261277MI51.351.2Samani, N. J. [23]2007GermanyCaucasians7221643MI50.262.5Meng, W. [24]2007Northern IrelandCaucasians482622MI46.055.2Iakoubova, O. [14]2008USACaucasians276519MI56.456.2Meiner, V. [25]2008USACaucasians505559MI46.045.2Serre, D. [26]2008SeveralSeveral789859MI61.661.2Morgan, T. M. [27]2008USACaucasians807637MI61.560.7Assimes, T. L. [28]2008USACaucasians505514CAD45.445.6Vennemann, M. M. [29]2008GermanyCaucasians7931121MI52.252.6Sutton, B. S. [30]2008USACaucasians1575970MI28.952.4Martinelli, W. [31]2008ItalyCaucasians1106383CAD61.458.0Herrera-Galeano, J. E. [32]2008USACaucasians3782652CAD46.9…”

Section: Resultsmentioning

confidence: 99%

“…[23]447529150522593162142382916379170.790.80Samani, N. J. [23]293328101662753228914530207712090.570.55Meng, W. [24]20322653261292696323328144300.420.37Iakoubova, O. [14]10413735256204593452077163220.360.06Meiner, V. [25]18722890216260836024086924260.160.78Serre, D. [26]335337117354402103100757111106080.03*0.55Morgan, T. M. [27]3223771082563047710215938164580.930.39Assimes, T. L. [28]162187831441831305113534714430.03*0.00*Vennemann, M. M. [29]311379103430528163100158513888540.441.00Sutton, B. S. [30]5455701...…”

Section: Resultsmentioning

confidence: 99%

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The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

Ruíz-Ramos¹,

Hernández‐Díaz²,

Tovilla-Zárate³

et al. 2015

Hereditas

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BackgroundGenetic factors play an important role in the pathogenesis of coronary heart disease (CHD). Kinesin-like protein 6 (KIF6) is a new candidate gene for CHD, since it has been identified as a potential risk factor. The aim of this study was to perform a systematic review and meta-analysis of previously published association studies between the Trp719Arg polymorphism of KIF6 and the development of CHD.MethodsStudies and abstracts investigating the relationship between the Trp719Arg polymorphism of KIF6 and subsequent risk for development of CHD were reviewed. Electronic search from Pubmed and EBSCO databases was performed between 1993 and 2014 to identify studies that fulfilled the inclusion criteria. To analyze the association we used the models: allelic, additive, dominant and recessive. Moreover, we conducted a sub-analysis by populations using the same four models.ResultsTwenty-three studies were included in the meta-analysis. The Trp719Arg polymorphism showed a significant association with CHD when the analysis comprised the population with myocardial infarction (MI) and the additive genetic model was used. Moreover, this polymorphism showed a protective association with CHD when the analysis comprised the whole population using the recessive genetic model.ConclusionsOur findings indicate that the Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing MI and that allele 719Arg may have a protective association to present CHD in all populations.PROSPERO registration CRD42015024602.Electronic supplementary materialThe online version of this article (doi:10.1186/s41065-015-0004-7) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

Ruíz-Ramos¹,

Hernández‐Díaz²,

Tovilla-Zárate³

et al. 2015

Hereditas

View full text Add to dashboard Cite

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“…(31) Association of the single nucleotide polymorphism (SNP) Y402H of the CFH gene with increased cardiovascular risk has been controversial. (32),(33),(34),(35) However, complement activation has been shown to be higher in individuals presenting with ACS,(36) and recently to be associated with an anti-coagulant role. (37) The biological activity of CFH binding to MDA-LDL decreased by ~12% post PCI, and there was an increase of ~6% at 3-7 days post PCI that remained until 6 months.…”

Section: Discussionmentioning

confidence: 99%

Acute and long-term effect of percutaneous coronary intervention on serially-measured oxidative, inflammatory, and coagulation biomarkers in patients with stable angina

Leibundgut

Lee

Strauss

et al. 2016

J Thromb Thrombolysis

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Objectives To derive insights into the temporal changes in oxidative, inflammatory and coagulation biomarkers in patients with stable angina undergoing percutaneous coronary intervention (PCI). Background PCI is associated with a variety of biochemical and mechanical stresses to the vessel wall. Oxidized phospholipids are present on plasminogen (OxPL-PLG) and potentiate fibrinolysis in vitro. We recently showed that OxPL-PLG increase following acute myocardial infarction, suggesting that they are involved in atherothrombosis. Methods Plasma samples were collected before, immediately after, 6 and 24 hours, 3 and 7 days, and 1, 3, and 6 months after PCI in 125 patients with stable angina undergoing uncomplicated PCI. Plasminogen levels, OxPL-PLG, and array of 16 oxidative, inflammatory and coagulation biomarkers were measured with established assays. Results OxPL-PLG and plasminogen declined significantly immediately post-PCI, rebounded to baseline, peaked at 3 days and slowly returned to baseline by 6 months (p<0.0001 by ANOVA). The temporal trends to maximal peak in biomarkers were as follows: immediately post PCI: OxPL-apoB and lipoprotein (a); Day 1- the inflammatory biomarkers IL-6 and CRP; Day 3- coagulation biomarkers OxPL-PLG, plasminogen and tissue plasminogen activity; Day 3-7- plasminogen activator inhibitor; and Day 7-30- complement factor H binding to malondialdehyde-LDL, PAI-1 activity, MDA-LDL IgG and IgM, CuOxLDL IgM, and ApoB-IC IgM and IgG. Most of the biomarkers trended to baseline by 6 months. Conclusions PCI results in a specific, temporal sequence of changes in plasma biomarkers. These observations provide insights into the effects of iatrogenic barotrauma and plaque disruption during PCI and suggest avenues of investigation to explain complications of PCI and development of targeted therapies to enhance procedural success.

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“…Each family had at least 1 member affected with early-onset CHD (disease onset ≤55 years for males and ≤60 years for females) and at least 1 unaffected sibling and/or both parents surviving. 6 The study was approved by the Research Ethics Committee of Queen's University Belfast and informed consent was given by all subjects.…”

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confidence: 99%

Variants in the Nestin Gene and Coronary Heart Disease

Wang

Patterson

Belton

et al. 2008

Circ J

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BackgroundThe intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and ResultsThe 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required. (Circ J 2008; 72: 1538 -1539

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Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Cited by 12 publications

References 23 publications

The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

Acute and long-term effect of percutaneous coronary intervention on serially-measured oxidative, inflammatory, and coagulation biomarkers in patients with stable angina

Variants in the Nestin Gene and Coronary Heart Disease

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