Genetic variants in xenobiotic detoxification enzymes, antioxidant defenses and hormonal pathways as biomarkers of susceptibility to prostate cancer

Martínez-González, Luis Javier; Antúnez-Rodríguez, Alba; Vázquez-Alonso, Fernando; Hernández, Antonio F.; Álvarez-Cubero, M.J.

doi:10.1016/j.scitotenv.2020.138314

Cited by 11 publications

(2 citation statements)

References 46 publications

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“…The imbalances in peroxisomal H 2 O 2 metabolism have been associated with multiple oxidative stress-related human and animals disease states, and it can be linked to alterations in CAT activity [ 93 , 162 , 163 , 164 , 165 , 166 , 167 , 168 ]. CAT modulates the expression of numerous genes, i.e., CAT inhibition or overexpression can activate or inhibit the activity of NF-κB.…”

Section: Antioxidative Systems—the Main Player In Oxidative Response ...mentioning

confidence: 99%

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

Szechyńska‐Hebda

Ghalami

Kamran

et al. 2022

Cells

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In the environmental and organism context, oxidative stress is complex and unavoidable. Organisms simultaneously cope with a various combination of stress factors in natural conditions. For example, excess light stress is accompanied by UV stress, heat shock stress, and/or water stress. Reactive oxygen species (ROS) and antioxidant molecules, coordinated by electrical signalling (ES), are an integral part of the stress signalling network in cells and organisms. They together regulate gene expression to redirect energy to growth, acclimation, or defence, and thereby, determine cellular stress memory and stress crosstalk. In plants, both abiotic and biotic stress increase energy quenching, photorespiration, stomatal closure, and leaf temperature, while toning down photosynthesis and transpiration. Locally applied stress induces ES, ROS, retrograde signalling, cell death, and cellular light memory, then acclimation and defence responses in the local organs, whole plant, or even plant community (systemic acquired acclimation, systemic acquired resistance, network acquired acclimation). A simplified analogy can be found in animals where diseases vs. fitness and prolonged lifespan vs. faster aging, are dependent on mitochondrial ROS production and ES, and body temperature is regulated by sweating, temperature-dependent respiration, and gene regulation. In this review, we discuss the universal features of stress factors, ES, the cellular production of ROS molecules, ROS scavengers, hormones, and other regulators that coordinate life and death.

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Section: Antioxidative Systems—the Main Player In Oxidative Response ...mentioning

confidence: 99%

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

Szechyńska‐Hebda

Ghalami

Kamran

et al. 2022

Cells

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“…NGS has proven to be a significant tool for finding new altered genes, allowing for the diagnosis of many diseases, with an especially important role in less well-known diseases, such as HPC. Moreover, NGS helps expand our knowledge of control mechanisms of genetic expression with a high level of detail and accuracy, which is important for the comprehension of genotype-phenotype relationships among patients [4]. The implementation of "omics" data in clinical practice has generated a new framework in the study of health and the causes of disease; including new knowledge and approaches related to precision medicine.…”

Section: Introductionmentioning

confidence: 99%

OMICs Role in Hereditarian Prostate Cancer

Cuenca-Lopez¹,

Sánchez

Vázquez-Alonso

et al. 2020

The 1st International Electronic Conference on Genes: Theoretical and Applied Genomics

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Prostate cancer (PC) is one of the most prevalent tumours in the world, however, the hereditary (Hereditary PC; HPC) form is a rare pathology, that does not exceed 6%. Despite its very low incidence, a family history of PC in a first-degree relative multiplies the risk of suffering from PC by approximately two-fold. Therefore, the search for genetic variables associated with the detection, monitoring and treatment of the condition is paramount. In this study, we conduct deep screening of exomes by next-generation sequencing (NGS) analysis in search of new biomarkers. We performed this analysis in a family with a high incidence of PC. Our data reveal that variants in some genes, such as HIBCH and DPP4, are present in all HPC patients. Moreover, high-risk patients have unique additional variants, such as FANK1, TUBA3FP and ALDH3B2. These results provide a new set of promising biomarkers in HCP.

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The rs1801280 SNP is associated with non-small cell lung carcinoma by exhibiting a highly deleterious effect on N-acetyltransferase 2

Lawi

Al-Shuhaib

Amara³

2022

J Cancer Res Clin Oncol

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Genetic variants in xenobiotic detoxification enzymes, antioxidant defenses and hormonal pathways as biomarkers of susceptibility to prostate cancer

Cited by 11 publications

References 46 publications

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

OMICs Role in Hereditarian Prostate Cancer

The rs1801280 SNP is associated with non-small cell lung carcinoma by exhibiting a highly deleterious effect on N-acetyltransferase 2

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