Genetic variants in TNFα and the one-year cardiovascular outcome in patients with coronary heart disease

Schulz, Susanne; Schlitt, Axel; Lutze, Andrea; Lischewski, Sandra; Seifert, Tim; Dudakliewa, Tanya; Gawe, Robert; Werdan, Karl; Hofmann, Britt; Gläser, Christiane; Schaller, Hans‐Günter; Reichert, Stefan

doi:10.1016/j.ijcard.2013.03.074

Cited by 1 publication

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“…[8] As a complex disease, CHD results from the interaction between genetic and environmental factors. [9] Recent studies have suggested that the basic level and biological activity of TNF-a and IL-6 can be influenced by gene polymorphism, which may increase the risk of CHD [10,11] C863A of TNF-a and C174G of IL-6 are the mostly investigated but the results remain inconsistent. Asifa et al [12] considered that the TNF-a C863A gene polymorphism was associated with the pathogenesis of CHD through case-control study in Pakistan, while Chu et al [13] research in China drew an opposite conclusion.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease

Jiang¹,

Zhao²,

Zhao

et al. 2019

Medicine

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To evaluate the association between gene polymorphisms of TNF-α G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12.0 software.Thirty-five articles were included. Among them, 17 studies were related to TNF-α (G308A) gene mutation and CHD, and 18 studies examined IL-6 (C174G) gene mutation. According to the results of subgroup analysis of ethnicity, it suggested that TNF-α (G308A) polymorphism was not significantly associated with CHD risk under all models in Asians (P > .05). There were no connected of IL-6 C174G polymorphism with CHD risk under all models in Caucasians after subgroup analysis (P > .05).The present evidence shows that TNF-α (G308A) have no connected with the risk of CHD in Asians; IL-6 (C174G) gene were not associated with the risk of CHD in Caucasians.

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