Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia

Metayer, Catherine; Scélo, Ghislaine; Chokkalingam, Anand P.; Barcellos, Lisa F.; Aldrich, Melinda C.; Chang, Jeffrey S.; Guha, Neela; Urayama, Kevin Y.; Hansen, Helen M.; Block, Gladys; Kiley, Vincent A.; Wiencke, John K.; Wiemels, Joseph L.; Buffler, Patricia A.

doi:10.1007/s10552-011-9795-7

Cited by 49 publications

(60 citation statements)

References 53 publications

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“…A total of 45 publications were achieved by an extensive search. We excluded 17 studies and one population of a study (five subjects were overlapped in other publications (Koushik et al, 2006;Wang et al, 2006;Vainer et al, 2010;Mohammad et al, 2011;Naushad et al, 2011a); genotype frequencies of eight studies were not provided (Lee et al, 2007;Gibson et al, 2011;Metayer et al, 2011;Naushad et al, 2011b;Piskac-Collier et al, 2011;Galbiatti et al, 2012;Lautner-Csorba et al, 2013;Swartz et al, 2013); and four studies (Wang et al, 2007b;Yu et al, 2007;Patino-Garcia et al, 2009;Curtin et al, 2011;Naushad et al, 2012) and one of populations in a study (Steck et al, 2008) did not conform to HWE). A total of 28 case-control studies with 29 populations met our inclusion criteria (Skibola et al, 2002;Hishida et al, 2003;Chen et al, 2004;Skibola et al, 2004;Lightfoot et al, 2005;Zhang et al, 2005;Niclot et al, 2006;Hazra et al, 2007;Lim et al, 2007;Lissowska et al, 2007;Moore et al, 2007;van den Donk et al, 2007;Wang et al, 2007a;Cheng et al, 2008;Guerreiro et al, 2008;Steck et al, 2008;Berglund et al, 2009;…”

Section: Methodsmentioning

confidence: 99%

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

Zhong

Zhang²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a more precise estimation of the association between C1420T and cancer risk, the present meta-analysis of 28 available studies with 15,121 cases and 18,023 controls was conducted. The results revealed that there was no significant association between the polymorphism and cancer risk overall. In stratified analysis by cancer type (breast cancer, gastrointestinal cancer, leukemia, lymphoma, and others), the results showed that 1420T allele was associated with decreased risk in leukemia . In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk. Large well-designed epidemiological studies will be necessary to validate the risk identified in the current meta-analysis.

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Section: Methodsmentioning

confidence: 99%

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

Zhong

Zhang²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…[16][17][18][19][20][21][22][23], 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR; refs. 17,22,[24][25][26][27][28], methylenetetrahydrofolate dehydrogenase (MTHFD1; refs. 22,25,27,29), thymidylate synthetase (TS/ TYMS; refs.…”

Section: Introductionmentioning

confidence: 99%

“…17,22,[24][25][26][27][28], methylenetetrahydrofolate dehydrogenase (MTHFD1; refs. 22,25,27,29), thymidylate synthetase (TS/ TYMS; refs. 17,20,22,25,[29][30][31][32], and reduced folate carrier (RFC1; refs.…”

Section: Introductionmentioning

confidence: 99%

“…22,25,27,29), thymidylate synthetase (TS/ TYMS; refs. 17,20,22,25,[29][30][31][32], and reduced folate carrier (RFC1; refs. 26,27,30,32).…”

Section: Introductionmentioning

confidence: 99%

“…A Californian study reported interactions between maternal folic acid use and filial genotype at specific loci on cystathionine-beta-synthase (CBS), MTRR, and TYMS genes (25), while a French study found no evidence of such interactions with polymorphisms in the MTHFR or MTRR genes (24).…”

Section: Introductionmentioning

confidence: 99%

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Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia

Milne

Greenop

Scott

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003)(2004)(2005)(2006)(2007).Methods: All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C>T, MTHFR 1298A>C, MTRR 66A>G, MTR 2756 A>G, MTR 5049 C>A, CBS 844 Ins68, and CBS 2199 T>C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched vari-

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Childhood leukemia incidence in California: High and rising in the Hispanic population

Giddings

Whitehead²,

Metayer

et al. 2016

Cancer

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Background High rates of childhood leukemia incidence have been reported in Latin America and among Hispanic children in the United States. California’s large Hispanic population affords an important opportunity to perform a detailed analysis of the leukemia burden among Hispanic children. Methods Leukemias diagnosed among non-Hispanic white (NHW), Hispanic, African American (AA), and Asian/Pacific Islander (API) children, aged 0 to 19 years, between January 1, 1990 and December 31, 2012 were obtained from the California Cancer Registry (n=11,084). Age-adjusted incidence rates (AAIR), standardized rate ratios (SRR), and secular trends in incidence (annual percent change [APC]) were analyzed by subtype, race/ethnicity, sex, and age. Results Compared to NHWs, acute lymphoblastic leukemia (ALL) incidence was higher among Hispanics (SRR=1.32) and lower among AAs (SRR=0.55) and APIs (SRR=0.91). From 1990 to 2012, ALL incidence increased overall (APC=1.1%), among males (APC=1.0%), females (APC=1.3%), Hispanics (APC=1.1%), AAs (APC=1.9%), AA males (APC=2.8%), API males (APC=1.9%), and Hispanic females (APC=1.5%). ALL increased among Hispanic males aged 15 to 19 years (APC=2.5%) and Hispanic females aged 0 to 4 and 15 to 19 years (APC=2.2% and 1.9%, respectively). Acute myeloid leukemia (AML) incidence did not differ among racial/ethnic groups. From 1990 to 2012, overall AML incidence remained stable but increased among Hispanics (APC=1.2%), females (APC=1.0%), Hispanic females (APC=2.3%), and Hispanic females aged 15 to 19 years (APC=3.4%). Conclusions Notable differences in childhood leukemia incidence among four racial/ethnic groups in California were observed. Factors which may contribute to these differences include differential exposure to carcinogens and/or genetic susceptibility.

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Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia

Cited by 49 publications

References 53 publications

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia

Childhood leukemia incidence in California: High and rising in the Hispanic population

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