Genetic variants in RNA-induced silencing complex genes and prostate cancer

Abstract

According to our data, rs3742330, rs4961280 and rs7813 qualify for potentially protective genetic variants against PCa progression. These variants were not shown to be associated with PCa risk.

Association of <em>GEMIN4</em> gene polymorphism and the risk of cancer: a meta-analysis

“…In general, 70 relevant articles were originally chosen from different electronic databases. According to the inclusion and exclusion criteria, 55 articles were eliminated and 15 qualified articles (9 articles referring to rs2740348, 15 , 18 , 22 , 28 11 articles referring to rs7813, 15 – 17 , 19 , 22 – 25 , 29 – 31 and 5 articles referring to rs3744741 15 , 16 , 22 – 24 ) were finally included in the meta-analysis ( Figure 1 ). Specifically, details of the eliminated articles are shown in Table S1 .…”

“…Genetic variants in the GEMIN4 gene might lead to a decreased inhibitory effect on the proliferation of hepatocarcinoma cells and simultaneously have an impact on the DNA repair system by altering the expression of proliferation-associated genes and DNA repair genes. 32 Several studies have found that genetic variants in the GEMIN4 gene not only alter the susceptibility to cancer, 15 – 19 but also influence the survival time of patients with cancer. 33 , 34 However, as far as we know, most of these studies are small-scale case–control studies.…”

“…Liu et al found that rs7813 was associated with an increased risk of prostate cancer, 15 and Nikolić et al also found a significant association between rs7813 and the risk of prostate cancer progression. 19 However, Fang et al found that rs7813 was associated with decreased risk of lung cancer. 17 A similar protective effect was found in ovarian and breast cancers.…”

“… 12 , 13 Furthermore, the alteration in miRNA biogenesis genes may be associated with susceptibility to cancer probably by influencing the function of miRNAs. 14 Furthermore, a body of evidence has indicated that some single-nucleotide polymorphisms (SNPs) in the GEMIN4 gene, a major miRNA biogenesis gene, are associated with the risk of several types of cancer, 15 – 19 but the published results are inconsistent. 15 – 17 Therefore, in the present study, we undertook a meta-analysis to analyze the association between three major SNPs in the GEMIN4 gene (rs2740348, rs7813, and rs3744741) and the risk of cancer based on published articles.…”

A pan-cancer atlas of somatic mutations in miRNA biogenesis genes

“…Furthermore, it was shown that some SNPs in miRNA biogenesis genes are associated with the risk of various cancers. Examples include (i) the rs3742330 (A>C) SNP located in the 3' UTR of DICER1 that affects DICER1 mRNA stability and is associated with susceptibility and malignancy in gastric cancer [74,75], increased survival of Tcell lymphoma patients [76] and lower prostate cancer aggressiveness [77]; (ii) the rs78393591 SNP in DROSHA and rs114101502 SNP in ZCCHC11 (TUTase responsible for pre-miRNA uridylation and subsequent DICER1 cleavage inhibition) associated with the risk of breast cancer [78]; and (iii) the rs11786030 and rs2292779 SNPs in AGO2, rs9606250 SNP in DGCR8, and rs1057035 SNP in DICER1 associated with the survival of breast cancer patients [79]. Additionally, the SNPs rs2740348 C>G and rs7813 C>T in GEMIN4, a gene involved in miRISC formation and miRNA-duplex unwinding, were implicated in the risk of several cancers, although the results were not conclusive [80][81][82][83][84].…”