Genetic variants in oxytocin receptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in chinese adolescents

Zhang, Yanmei; Wu, Chunxia; Chang, Hongjuan; Yan, Qiuge; Wu, Linguo; Yuan, Shanshan; Xiang, Jingjing; Wen, Huaxuan; Yu, Yizhen

doi:10.1016/j.jad.2017.12.024

Cited by 22 publications

(14 citation statements)

References 48 publications

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“…The 3’UTR rs6770632(G) has been associated with VABS scores 27 and persistent, extreme aggression, with the C and T alleles affecting male and female children, respectively 35 . rs237885(T) has been associated with callous/unemotional traits 35 , ASD 36 , schizophrenia diagnosis 37 and higher risk of aggression 38 , while the G allele is linked to altruistic allocations in the Dictator Game 30 .…”

Section: Resultsmentioning

confidence: 99%

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Theofanopoulou

Andirkó

Boeckx

et al. 2018

Preprint

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10Modern humans' lifestyle strongly depends on complex social skills like empathy, tolerance and cooperation. Variation in the oxytocin receptor (OXTR) and the arginine-vasopressin receptors (AVPR1A, AVPR1B genes) has been widely associated with diverse facets of social cognition, but the extent to which these variants may have contributed to the evolution of human prosociality remains to be elucidated. In this study, we compared the OXTR, AVPR1A and AVPR1B DNA sequences of modern humans to those of our closest extinct and extant relatives, and then clustered the variants we identified based on their distribution in the species studied. This clustering, along with the functional importance retrieved for each variant and their frequency in different modern-human populations, is then used to determine if any of the OXTR, AVPR1A and AVPR1B-variants might have had an impact at different evolutionary stages. We report a total of 29 SNPs, associated with phenotypic effects ranging from clearly pro-social to mixed or antisocial. Regarding modern human-specific alleles that could correlate with a shift towards prosociality in modern-humans, we highlight one allele in AVPR1A (rs11174811), found at high frequency and linked to prosocial phenotypes in modern humans, while the ancestral allele is associated with antisocial phenotypes. We also report three sites of putatively convergent changes between modern humans and bonobos (rs237897(A), rs2228485(G) and rs1042615(A)), and note the absence of such a convergent pattern between modern humans and chimpanzees. Finally, we observe the high concentration of 'modern human specific' alleles in vasopressin receptors not paralleled in the oxytocin receptor. 11 1 Introduction 12 Oxytocin (OXT) and vasopressin (AVP) are important neurotransmitters that function through their respective receptors to 13 regulate a diverse set of biological processes, such as pregnancy and uterine contractions, milk-ejection, copulation and orgasm, 14 attachment between mothers and their young, bond formation, suppression of stress, thermoregulation, olfactory processing, 15 eye-contact and recognition of familiar individuals 1 . OXT and AVP are closely related structurally and evolutionarily: they 16 have been argued to be the product of a local duplication event that took place before the origin of vertebrates 2 , and they only 17 differ in two (of the nine) amino acids, although they display differences at a functional level 1 . Each binds to their respective 18 receptor(s) (OXTR in the case of oxytocin, and AVPR1A, AVPR1B, and AVPR2 in the case of vasopressin), but their molecular 19 similarities allow for crosstalk in the brain and peripheral organs 3 . 20Variation in the genes that code for OXT and AVP receptors (OXTR and mainly AVPR1A and AVPR1B) have long been 21 associated with different social behaviors 4 . Single Nucleotide Polymorphisms (SNPs) in these genes in modern humans have 22 been claimed to be implicated in altruism, face recognition, stress levels and empathy, but also in socioco...

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Section: Resultsmentioning

confidence: 99%

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Theofanopoulou

Andirkó

Boeckx

et al. 2018

Preprint

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“…In the present study, we sought to shed more light on childhood maltreatment and its interaction with OXTR gene. Several lines of evidence show that there are interactions between the OXTR gene polymorphisms and childhood maltreatment; for instance, OXTR rs53576 G-allele carriers who had experienced maltreatment in childhood were observed to increase conduct problems in adolescence [30], and maltreated individual who carried the rs237885 TT genotype in OXTR gene had an increased risk of aggression [31]. In addition, the interaction between the OXTR gene and childhood maltreatment could affect the function or structure of the brain, especially the amygdala [32], which is responsible for emotional regulation what BPD patients lack.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China

2020

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Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 Chinese Han male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by selfreported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

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Section: Introductionmentioning

confidence: 99%

Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

Zhang

Liu²,

Chen

et al. 2020

Preprint

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Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

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Genetic variants in oxytocin receptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in chinese adolescents

Cited by 22 publications

References 48 publications

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China

Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

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