Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle

Zhao, Chunping; Raza, Sayed Haidar Abbas; Khan, Rajwali; Sabek, Ahmed; Khan, Samiullah; Ullah, Irfan; Memon, Sameeullah; El-Aziz, Ayman Hassan Abd; Shah, Mujahid Ali; Li, Shijun; Wang, Liyun; Liu, Xuchun; Zhang, Yiwei; Gui, Linsheng; Liu, Zan

doi:10.1016/j.ygeno.2020.03.018

Cited by 19 publications

(11 citation statements)

References 43 publications

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“…Wang et al [ 1 ] detected two SNPs in exon 3 and an indel in intron 2 from five breeds with total of 645 sheep samples using PCR-SSCP analysis, and found genotype AA from Romney sheep associated with carcass lean meat yield. More MYF5 sequence variation has been described in cattle [ 12 , 13 , 22 ] and pigs [ 10 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…In pigs, variation of MYF5 has been found to be associated with meat quality including loin-eye area, tenderness, total fiber number, water moisture content, and pH value of longissimus dorsi [ 7 , 8 , 9 , 10 ]. While in cattle, variation in MYF5 affects growth and meat quality traits including birth, fat, carcass weight, and body length [ 11 , 12 , 13 ]. In addition, variants of MYF5 have been reported to be associated with growth and reproductive traits in chicken [ 14 ], and showed differences in carcass and meat quality traits in pigeon [ 15 ] and rabbit [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Novel Single Nucleotide Polymorphisms and Haplotype of MYF5 Gene Are Associated with Body Measurements and Ultrasound Traits in Grassland Short-Tailed Sheep

Zhang

Liu

Hao

et al. 2022

Genes

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Myogenic factor 5 plays active roles in the regulation of myogenesis. The aim of this study is to expose the genetic variants of the MYF5 and its association with growth performance and ultrasound traits in grassland short-tailed sheep (GSTS) in China. The combination technique of sequencing and SNaPshot revealed seven SNPs in ovine MYF5 from 533 adult individuals (male 103 and female 430), four of which are novel ones located at g.6838G > A, g.6989 G > T, g.7117 C > A in the promoter region and g.9471 T > G in the second intron, respectively. Genetic diversity indexes showed the seven SNPs in low or intermediate level, but each of them conformed HWE (p > 0.05) in genotypic frequencies. Association analysis indicated that g.6838G > A, g.7117 C > A, g.8371 T > C, g.9471 T > G, and g.10044 C > T had significant effects on growth performance and ultrasound traits. The diplotypes of H1H3 and H2H3 had higher body weight and greater body size, and haplotype H3 had better performance on meat production than the others. In addition, the dual-luciferase reporter assay showed that there are two active regions in the MYF5 promoter located at −1799~−1197 bp and −514~−241 bp, respectively, but g.6838G > A and g.7117 C > A were out of the region, suggesting these two SNPs influence the phenotype by other pathway. The results suggest that the MYF5 gene might be applied as a promising candidate of functional genetic marker in GSTS breeding.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Single Nucleotide Polymorphisms and Haplotype of MYF5 Gene Are Associated with Body Measurements and Ultrasound Traits in Grassland Short-Tailed Sheep

Zhang

Liu

Hao

et al. 2022

Genes

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“…Population genetic indexes, such as gene heterozygosity (H e ), gene homozygosity (H o ), effective allele numbers (N e ) and polymorphism information content (PIC), were analyzed according to Chakraborty and Nei [20]. LD plot was performed to analyze the Linkage disequilibrium (LD)of SNPs and haplotype block of Haploview software was used to obtain the haplotypes [21,22]. The diplotype was assessed according to the SNPs and haplotypes.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the Growth Hormone Releasing Hormone Receptor Gene Affect Body Conformation Traits in Chinese Dabieshan Cattle

Zhao

Jin

Liu

et al. 2022

Animals

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This study was performed to expose the polymorphisms of the growth hormone-releasing hormone receptor gene in Chinese Dabieshan cattle, evaluate its effect on body conformation traits, and find potential molecular markers in Chinese cattle. The GHRHR structure and the phylogenetic tree were analyzed using bioinformatics software. The polymorphism of the GHRHR gene in 486 female cattle was genotyped by PCR-RFLP and DNA sequencing, and the association between SNPs and body conformation traits of Chinese Dabieshan cattle was analyzed by one-way ANOVA in SPSS software. GHRHR was often conserved in nine species, and its sequence of cattle was closest to sheep and goats. Six polymorphic SNPs were identified, g.10667A > C and g.10670A > C were missense mutation. The association analysis indicated that the six SNPs significantly influenced the body conformation traits of Chinese Dabieshan cattle (p < 0.05). Six haplotypes were identified and Hap1 (-CAACGA-) had the highest frequency (36.10%). The Hap3/5 (-GCCCCCGGAAGG-) exhibited a significantly greater wither height (WH), hip height (HH), heart girth (HG), and hip width (HW) (p < 0.05). Overall, the polymorphisms of GHRHR affected the body conformation traits of Chinese Dabieshan cattle, and the GHRHR gene could be used as a molecular marker in Dabieshan cattle breeding programs.

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“…The SREBP1 gene has an essential role in the lipogenesis and fatty acid composition in fat cells and was consequently considered to influence the beef nutritional quality [53]. The genetic variants of MYF5 genes were associated with growth traits, genetic indices, morphological scores, backfat thickness and meat tenderness [54][55][56]. The polymorphisms of MYOD1 and MYF6 genes were found to be important for growth and muscle development, carcass traits and beef quality [57].…”

Section: State Of Inter-population Genetic Diversitymentioning

confidence: 99%

Food Resources Biodiversity: The Case of Local Cattle in Slovakia

et al. 2021

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This study aimed to assess the level of biodiversity in selected local cattle populations as important food resources in Slovakia. The biodiversity level was derived from the genome-wide data collected for dairy (Jersey), dual-purpose (Slovak Pinzgau, Slovak Spotted), and beef breeds (Charolais, Limousine). The commonly used indices, genomic inbreeding (FROH, FGRM, FHOM, FUNI) and effective population size (NeLD), were used to quantify the impact of relatives mating on the genome of analysed populations. Even if the low NeLD estimates signalise significant loss of genetic variability within populations, the genomic inbreeding under 1% (except Jersey) showed that the intensity of diversity loss is not so rapid and can be managed by the re-arrangement of long-term breeding strategies. The analysis of genetic differentiation degree across populations assumed that the specialisation of breeds during their grading-up led to the specific nucleotide changes, especially in genes responsible for preferred phenotypic traits. The breed-specific differences observed mainly in the genome of Charolais (carcass traits) and Jersey (milk production traits) populations resulted from the polymorphisms in CAPN1 (μ-calpain) and CSN1S2 (casein alpha s2) genes, respectively. Obtained results confirmed that the specific haplotypes are strongly associated with the genetic nature of breed depending on production type.

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Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle

Cited by 19 publications

References 43 publications

Novel Single Nucleotide Polymorphisms and Haplotype of MYF5 Gene Are Associated with Body Measurements and Ultrasound Traits in Grassland Short-Tailed Sheep

Novel Single Nucleotide Polymorphisms and Haplotype of MYF5 Gene Are Associated with Body Measurements and Ultrasound Traits in Grassland Short-Tailed Sheep

Polymorphisms of the Growth Hormone Releasing Hormone Receptor Gene Affect Body Conformation Traits in Chinese Dabieshan Cattle

Food Resources Biodiversity: The Case of Local Cattle in Slovakia

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