Genetic variants in lncRNAH19are associated with the risk of bladder cancer in a Chinese population

Abstract

The long non-coding RNA (lncRNA) H19 as an imprinted gene transcribed from only the maternal allele has the vital role in carcinogenesis. Aberrant H19 expression is involved in bladder cancer development. In this study, we explored the association between single nucleotide polymorphisms (SNPs) in H19 and bladder cancer risk. Four tagging SNPs (tagSNPs) were selected from the 1000 Genomes Project database. In total, 1049 bladder cancer cases and 1399 controls were recruited in this case-control study. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by using unconditional univariate and multivariate logistic regression models to evaluate associations between the H19 tagSNPs genotypes and risk of bladder cancer. We found a statistically significant increased risk of bladder cancer in the carriers of the rs217727 AA genotype compared with carriers of GG/GA genotype (OR = 1.31, 95% CI = 1.03-1.67). The subsequently stratified analyses also revealed that the H19 rs217727 AA genotype remarkably elevated the risk of bladder cancer in subgroups of young subjects (OR = 1.80, 95% CI = 1.16-2.81), males (OR = 1.44, 95% CI = 1.10-1.89) and smokers (OR = 1.55, 95% CI = 1.06-2.27), as well as high tumour grade (OR = 1.89, 95% CI = 1.23-2.91) and invasive disease (OR = 1.62, 95% CI = 1.01-2.60). This finding indicates that the rs217727 polymorphism is significantly associated with the risk of bladder cancer.

H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

“…Our results further revealed the critical in uence of G and A genotype in H19 rs217727. In line with our observations, the study has revealed that the carriers of rs217727 AA genotype had a signi cantly increased risk of bladder cancer in young male patients [59]. Studies demonstrated T variant of rs217727 was strongly associated with an increased risk of coronary artery disease (CAD) and gastric cancer (GC) [60,61].…”

Potential of long non‐coding RNAs in cancer patients: From biomarkers to therapeutic targets

“…The rs13252298 and rs1456315 were associated with significantly decreased risks of CRC. Similarly, rs217727 AA in H19 and rs8506G > A in lincRNA‐NR_024015 are associated with increased risk of bladder cancer and non‐cardia gastric cancer, respectively.…”

A noncoding RNA LINC00504 interacts with c‐Myc to regulate tumor metabolism in colon cancer

“…From a functional perspective, lncRNAs are implicated in complex cellular processes via diverse mechanisms including titration of transcription factors, sponging microRNAs (miRNAs) and recruitment of chromatin modifying enzymes . For example, lncRNA‐H19 could interact with methyl‐CpG‐binding domain protein 1 to induce H3K9 methyltransferase to imprinted gene network . Furthermore, lncRNA PVT1 can promote angiogenesis via recruiting STAT3 and STAT3 in turn transactivate PVT1 expression .…”