Abstract:IntroductionFew studies have been conducted into neurogenic inflammation and neuroinflammation in respect of migraine. However, evidence suggests that the immune system may exert an influence over trigeminal activation and cortical spreading depression in individuals suffering from migraine. The interleukin (IL)-18 is a pro-inflammatory cytokine and increased plasma levels have been confirmed in individuals with migraine. However, as yet, the genetic variants of IL-18 have not been investigated in the context … Show more
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