volume 8, issue 7, P1364-1383 2016
DOI: 10.18632/aging.100986
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Jacob J.E. Koopman, Jeroen Pijpe, Stefan Böhringer, David van Bodegom, Ulrika K. Eriksson, Hernando Sanchez-Faddeev, Juventus B. Ziem, Bas Zwaan, P. Eline Slagboom, Peter de Knijff, Rudi G.J. Westendorp

Abstract: Human survival probability and fertility decline strongly with age. These life history traits have been shaped by evolution. However, research has failed to uncover a consistent genetic determination of variation in survival and fertility. As an explanation, such genetic determinants have been selected in adverse environments, in which humans have lived during most of their history, but are almost exclusively studied in populations in modern affluent environments. Here, we present a large-scale candidate gene …

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