Genetic variants at 6p21.1 are associated with head and neck cancer in Chinese Han population

Wang, Ruixia; Zhu, Lucheng; Zhang, Yu; Miao, Limin; Ma, Hongxia; Yuan, Hua; Chen, Ning

doi:10.3233/cbm-140442

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Wang et al . also found that rs2494938 SNP was associated with an increased risk of head and neck cancer in a Chinese Han population [14]. We found that two additional SNPs, at rs1321311 and rs9363918, were also associated with shorter survival in LC patients.…”

Section: Discussionsupporting

confidence: 60%

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Chen

et al. 2016

Oncotarget

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We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15–4.50), 2.17 (1.45–3.25), 2.39 (1.58–3.62), 3.29 (2.10–5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07–2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.

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Section: Discussionsupporting

confidence: 60%

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Chen

et al. 2016

Oncotarget

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“…Until now, evidences have confirmed the association of the polymorphism rs2285947 in DNAH11 with the higher risk of human cancers, such as ovarian cancer, head and neck cancer, lung cancer, non-cardia gastric cancer and esophageal squamous cell carcinoma [14, 26, 27]. We found that the GA/AA genotype of rs2285947 exhibited a significant association with poorer survival than the GG genotype among ESCC patients.…”

Section: Discussionsupporting

confidence: 56%

Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma

Wang

Wei

et al. 2019

BMC Med Genet

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Background Genome wide association study (GWAS) has become the major means to screen for the genetic variants associated with risk and prognosis of different diseases. A recent GWAS has discovered three novel intronic single nucleotide polymorphisms in genes LRFN2 (rs2494938), DNAH11 (rs2285947) and PLCXD2 (rs2399395) that are associated with altered risk of esophageal squamous cell carcinoma (ESCC) among Han Chinese populations. However, the prognostic significance of these variations in ESCC remains unclear. Methods To investigate the association of three novel single nucleotide polymorphisms (rs2494938, rs2285947, rs2399395) with the prognosis of ESCC patients, we recruited 287 ESCC patients treated with surgical resection and evaluated the potential significance of the three polymorphisms through Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazards regression models. Results The ESCC patients carrying genotype AA at rs2494938 had worse survival and genotype GG at 2285947 had better prognosis (Log-rank P = 0.003 and Log-rank P = 0.037, respectively). In addition, rs2494938 at 6p21.1 was independently associated with overall survival of ESCC patients in recessive model [AA vs. GG/GA, HR = 3.12, 95% CI = 1.43–6.83, P = 0.004], rs2285947 at 7p15.3 was independently associated with overall survival of ESCC patients in both dominant model [AA/GA vs. GG, HR = 1.59, 95% CI = 1.02–2.49, P = 0.042] and additive model [AA vs. GA vs. GG, HR = 1.45, 95% CI = 1.05–2.01, P = 0.025]. Conclusions This study demonstrated that the polymorphisms rs2494938 at 6p21.1 and rs2285947 at 7p15.3 may serve as independent prognostic biomarkers for ESCC, implying the potential biological role of their related genes ( LRFN2 and DNAH11 ) in the process of ESCC development. Electronic supplementary material The online version of this article (10.1186/s12881-019-0796-9) contains supplementary material, which is available to authorized users.

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Polymorphisms of theTERT-CLPTM1LGene Are Associated with Pharynx–Larynx Cancer

Zhou

et al. 2019

DNA and Cell Biology

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Genetic variants at 6p21.1 are associated with head and neck cancer in Chinese Han population

Abstract: Our results suggest that genetic variants at 6p21.1 may play an important role in HNC development in Han Chinese, and rs2494938 may be a candidate marker for HNC susceptibility.

Cited by 5 publications

References 26 publications

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients

Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma

Polymorphisms of theTERT-CLPTM1LGene Are Associated with Pharynx–Larynx Cancer

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