2011
DOI: 10.1093/carcin/bgr051
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Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population

Abstract: Two recent genome-wide association studies reported significant associations of genetic variants at 1q22, 10q23 and 20p13 with gastric cancer (GC) risk in Chinese populations. However, these findings have not been confirmed in other independent studies. Here, we performed an independent case-control study in a Chinese population by genotyping three loci (rs4072037A>G at 1q22, rs2274223A>G at 10q23 and rs13042395C>T at 20p13) in 1681 GC cases and 1858 controls. We found that rs4072037 at 1q22 and rs2274223 at 1… Show more

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Cited by 73 publications
(67 citation statements)
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“…SNPs rs4072037 and rs4460629 at locus 1q22 were significantly associated with an altered risk of GC, while no significant result for the SNPs at 10q23 was found, unlike previous reports (Abnet et al, 2010;Zhang et al, 2011).…”
Section: Discussioncontrasting
confidence: 92%
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“…SNPs rs4072037 and rs4460629 at locus 1q22 were significantly associated with an altered risk of GC, while no significant result for the SNPs at 10q23 was found, unlike previous reports (Abnet et al, 2010;Zhang et al, 2011).…”
Section: Discussioncontrasting
confidence: 92%
“…Though the GC GWAS conducted by Abnet et al has been replicated in an eastern Chinese population (Zhang et al, 2011), and the significant associations with risk of GC were found for rs4072037 at 1q22 and rs2274223 at 10q23. As far as we know, these findings have not been confirmed in other independent studies.…”
Section: Introductionmentioning
confidence: 95%
“…SNP rs4072037, located at the 5' end of exon 2 in MUC1 gene, controls the alternative splicing of MUC1 (Xu et al, 2009). In our study, the frequencies of AA, AG, and GG genotypes in controls were 62.7, 32.4, and 4.9%, respectively, which was similar to the data from other studies in Chinese population (Xu et al, 2009;Zhang et al, 2011) and those from HapMap Chinese data. And our results indicated that SNP rs4072037 was not significantly associated with non-cardia gastric cancer.…”
Section: Discussionsupporting
confidence: 92%
“…Furthermore, the same group failed to identify that rs4072037 was associated with the risk of gastric cancer in another study (He et al, 2013). Zhang et al found that SNP rs4072037 was significantly associated with both non-cardia gastric cancer and cardia gastric cancer in eastern Chinese population using a relatively larger sample size (Zhang et al, 2011). One possible explanation for the discrepancy between their study and ours is that the modulation of gastric cancer risk might depend not only on a single gene/single SNP, but also on a joint effect of multiple polymorphisms within different genes, or on close interaction between polymorphisms and environmental factors (Jiang et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
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