Genetic variants associated with the progression of hepatocellular carcinoma in hepatitis C Egyptian patients

No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: A meta-analysis

“…1). The all final collections were casecontrol studies [3,7,8,10,12,24]. As listed in Table 1, the included studies were 3 for breast cancer, 2 for colorectal cancer, 1 for hepatocellular carcinoma, 1 for esophageal cancer and 1 for Non-Hodgkin lymphoma.…”

Role of iron in hepatocellular carcinoma

“…In patients with chronic liver disease and mild iron overload, conflicting results concerning a possible association between HFE status and HCC have been reported (Table 2). [12][13][14][15] In a prospective study of 301 consecutive patients with cirrhosis, it was found that liver iron overload and heterozygosity for the C282Y HFE mutation were associated with a higher risk of HCC in patients with alcoholic Experimental models, humans Figure 2 The role of iron in liver disease. Oxidative stress in the liver can be induced by HCV, alcohol, NASH, hemochromatosis, and inflammation.…”

Genetic polymorphism of IL-23R influences susceptibility to HCV-related hepatocellular carcinoma

“…However, Langowski et al [27] suggested that IL-23 was a cancer-associated cytokine. It has recently been shown that IL-23 suppresses innate immunity in several mouse carcinogenesis models [28], indicating that IL-23 plays a role in carcinogenesis above and beyond its role in chronic inflammation. Xu et al [15] found the association of IL-23R rs6682925 and rs1884444 polymorphisms and the risk of HCC in a Chinese population.…”