Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study

Bhattacharjee, Esha; Ayushi,; Das, Chitrarpita; Bal, Vineeta; Bhatnagar, Shinjini; Das, Bhabatosh; Desiraju, Bapu Koundinya; Kshetrapal, Pallavi; Misra, Sumit; Natchu, Uma Chandra Mouli; Rath, Satyajit; Sachdeva, Kanika; Sharma, Dharmendra; Singh, Amanpreet; Sopory, Shailaja; Thiruvengadam, Ramachandran; Wadhwa, Nitya; Maitra, Arindam; Majumder, Partha P.; Maiti, Tushar Kanti; Bahl, Monika; Bansal, Shubra; Mehta, Umesh Kumar; Sharma, Sunita; Sindhu, Brahmdeep; Arya, Sugandha; Bharti, Rekha; Chellani, Harish; Mittal, Pratima; Garg, Anju; Ramji, Siddharth; Khurana, Ashok; Tripathi, Reva; Gupta, Yashdeep; Hari, Smriti; Tandon, Nikhil; Gupta, Rakesh; Salunke, Dinakar M.; Nair, Balakrish G.; Kang, Gagandeep

doi:10.1016/j.lansea.2023.100190

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Controls were selected in a 2:1 ratio and matched to cases according to infant sex and delivery date. More than 99% of pregnant women in Kazakhstan receive their maternal care from these local health centers, therefore the risk of selection bias was considered as low [18]. All of the health care centers provided free maternal and child care for their target groups under the same conditions.…”

Section: Methodsmentioning

confidence: 99%

“…Some commonly reported maternal risk factors for PTB include socio-economic characteristics, a history of PTB [7,10], smoking during pregnancy [11], a short cervical length [12], periodontal diseases [13], multiple pregnancies [14], maternal overweight, chronic somatic diseases, and pregnancy complications [15][16][17]. Furthermore, genetic factors have been identified that predispose individuals to preterm labor [18]. Inadequate prenatal care services may also contribute to the disparities in preterm birth rates [19].…”

Section: Introductionmentioning

confidence: 99%

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Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study

Oralkhan,

Sarsenova,

Kopbayeva

et al. 2024

Ekologiya cheloveka (Human Ecology)

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Background: Preterm birth (PTB) continues to be a persistent health issue that significantly impacts neonatal morbidity and mortality worldwide. In Kazakhstan, the prevalence of preterm births is 7% making a substantial contribution to adverse health outcomes among infants. However, there is a lack of comprehensive research on the factors contributing to preterm birth in Kazakhstan. Aims: To study maternal factors associated with spontaneous PTB among Kazakh women. Methods: A case control study was conducted in three major reproductive hospitals in Atyrau, Aktobe and Kyzylorda from October 2022 to January 2023. The sample consisted of 90 cases with singleton live spontaneous PTB and 180 controls with spontaneous full-term delivery. Bivariate associations between categorical variables were assessed by chi-squared tests. Independent variables with p-values 0.1 in the bivariate analysis were entered into a conditional logistic regression model. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Maternal education, periodontitis, body mass index and a history of PTB in previous pregnancies were associated with PTB in bivariate analysis. In multivariable models, only prior PTB (OR=38.1; 95% CI: 8.34–142) and periodontal disease (OR=2.09; 95% CI: 1.15–3.80) were associated with an increased risk of extremely and very preterm births while higher education (OR=0.44; 95% CI: 0.19–0.98) and a history of PTB (OR=27.2; 95% CI: 5.38–137) were associated with moderate to late PTB. Conclusion: Our results are in line with the international evidence on prior PTB being the most important determinant of PTB in the index pregnancy. Moreover, our findings on the associations with periodontal disease underline the importance of a targeted, individualized and interdisciplinary antenatal care to the reduction in the prevalence of PTB.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study

Oralkhan,

Sarsenova,

Kopbayeva

et al. 2024

Ekologiya cheloveka (Human Ecology)

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Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth

Srivastava,

Monangi,

Ravichandran

et al. 2024

Clinics in Perinatology

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Does Precision-Based Medicine Hold the Promise of a New Approach to Predicting and Treating Spontaneous Preterm Birth?

Khan,

Singh,

Yovera Leyva

et al. 2024

IJTM

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Background: Preterm birth (PTB) is a leading cause of childhood disability, and it has become a key public health priority recognized by the World Health Organization and the United Nations. Objectives: This review will: (1) summarize current practice in the diagnosis and management of PTB, (2) outline developments in precision-based medicine for diagnostics to improve the care provided to pregnant women at risk of PTB, and (3) discuss the implications of current research in personalized medicine and the potential of future advances to influence the clinical care of women at risk of PTB. Methodology: This is a narrative literature review. Relevant journal articles were identified following searches of computerized databases. Key Results: Current and emerging technologies for the utility of personalized medicine in the context of PTB have the potential for applications in: (1) direct diagnostics to identify and target infection as one of the main known causes of PTB, (2) identifying novel maternal and fetal biomarkers, (3) the use of artificial intelligence and computational modeling, and (4) combining methods to enhance diagnosis and treatment. Conclusions: In this paper, we show how current research has moved in the direction of the targeted use of biomarkers in the context of PTB, with many novel approaches.

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Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study

Cited by 3 publications

References 46 publications

Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study

Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study

Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth

Does Precision-Based Medicine Hold the Promise of a New Approach to Predicting and Treating Spontaneous Preterm Birth?

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