Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine

Isaza, Carlos; Henao, Julieta; Beltrán, Leonardo; Porras-Hurtado, Liliana; González, Martha Elisa Nateras; Cruz, Raquel Aparecida Sales da; Carracedo, Ángel

doi:10.25100/cm.v44i1.1039

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…However, their study showed a strong association between other SNPs in the DβH gene (rs2073837 and rs1611131) when the three groups (healthy control, non-opioid-dependent, and opioid-dependent groups) [32] were compared indicating that the type of gene plays a significant role in establishing any associations. Another study by Isaza et al [27] involving the Columbian population showed no significant association between the DβH polymorphism and drug addiction which also supported our findings of lack of association between DβH rs1611115 and drug addiction. As for the SLC6A3 rs27072 gene, there was a significant difference at the genotypic level (χ 2 = 7.006, p = 0.030) when the drug dependence was compared with the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Our findings support the results of the previous study which relate the SLC6A3 gene with drug dependence. SLC6A3 polymorphism is more common in the drug dependence group as compared to the control group [27] which may be influenced by ethnicity. A higher frequency of T alleles (28%) was recorded in the Han Chinese population, which was slightly higher than that reported for the Caucasian (18-19%) polymorphism is lower in Caucasians as compared to the Asian community [28].…”

Section: Discussionmentioning

confidence: 99%

“…To date, the allelic and genotypic frequencies of D2 receptor gene (DRD2) TaqlA rs1800497, dopamine betahydroxylase (DβH) rs1611115, dopamine transporter SLC6A3 rs27972, and norepinephrine transporter (SLC6A2) rs3785157 have been reported among drug abusers in Chinese [25], Caucasian [26], Columbian [27], and Han Chinese [28] populations. However, to our knowledge, there is no similar data reported for the Malaysian population, so far which is very ethnically diversified since it consists of the three main ethnic groups (Malays, Indians, and Chinese).…”

Section: Introductionmentioning

confidence: 99%

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Influence of dopaminergic system gene polymorphisms on mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays

Bakar

Deeza-Syafiqah

Ahmad

et al. 2019

Egypt J Med Hum Genet

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Background: The dopaminergic pathways have previously been reported to be involved in drug dependence. The candidate gene involved in the dopaminergic function has been associated with substance abuse. Objective: The objective of the study is to investigate the possible association between dopaminergic system gene polymorphisms with mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays. The study has never been done anywhere else, due to its unique population of study subjects. Subjects and methods In this study, genetic polymorphisms of dopamine D2 receptor (DRD2) dopamine transporter (SLC6A3), dopamine beta-hydroxylase (DβH), and norepinephrine transporter (SLC6A2) in Malay males (n = 70) having mixed amphetamine-type stimulant (ATS) and opioid dependence were compared with those in control subjects (n = 87). DNA was extracted from leucocytes followed by single nucleotide polymorphism (SNP) determination using PCR-RFLP. The association of the gene with drug dependency was analyzed using chi-squared tests. Results: There was a significant difference between the genotype (χ 2 = 10.048, p < 0.01) and allele frequency (χ 2 = 14.039, p = 0.000) of the DRD2 rs1800497 gene in the drug dependence group as compared to the control. There was also a significant difference in DβH rs1611115 at the allelic (χ 2 = 4.483, p = 0.034) but not at genotypic levels (χ 2 = 7.572, p = 0.23) in both control and drug dependence groups. There was an association for SLC6A3 rs27072 with drug dependence at the genotypic level (χ 2 = 7.006, p = 0.030) although no significant difference exist at the allelic level (χ 2 = 2.091, p = 0.148). No significant difference was observed in SLC6A2 rs3785157 genes polymorphism at both genotype and allelic level in control and drug dependence group respectively (χ 2 = 0.94, p = 0.954) (χ 2 = 0.29, p = 0.865) indicating that these polymorphisms do not affect drug dependence. Conclusion: Our study suggests that DRD2 rs1800497, DβH rs1611115, and SLC6A3 rs27072 but not SLC6A2 rs3785157 are associated with drug-dependent behavior among Malaysian Malays.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of dopaminergic system gene polymorphisms on mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays

Bakar

Deeza-Syafiqah

Ahmad

et al. 2019

Egypt J Med Hum Genet

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“…In fact, the MTHFR C677T polymorphism has been associated with depression in the context of traumatic stress in early life (Lok et al, 2013), again pointing to genetic and epigenetic determinants of stress-induced negative affect. Another genetic study on Colombian population indicated an association between a polymorphism of the SLC6A3 gene, which encodes the DA transporter or DAT, and addiction to heroin or cocaine (Isaza et al, 2013). Similarly, the same polymorphism was found to be correlated with cocaine dependence in a Brazilian sample ( n = 699) (Guindalini et al, 2006).…”

Section: Latin American Non-clinical Studies and Translational Effortsmentioning

confidence: 99%

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience

et al. 2018

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Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain’s reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Indeed, the HPA axis, the autonomic nervous system, and the extended amygdala, among other brain stress systems, interact with the brain’s reward circuit involved in addictive behaviors. There has been a growing interest in studying the molecular, cellular, and behavioral mechanisms of stress and addiction in Latin-America over the last decade. Nonetheless, these contributions may not be as strongly acknowledged by the broad scientific audience as studies coming from developed countries. In this review, we compile for the first time a series of studies conducted by Latin American-based neuroscientists, who have devoted their careers to studying the interaction between stress and addiction, from a neurobiological and clinical perspective. Specific contributions about this interaction include the study of CRF receptors in the lateral septum, investigations on the neural mechanisms of cross-sensitization for psychostimulants and ethanol, the identification of the Wnt/β-catenin pathway as a critical neural substrate for stress and addiction, and the emergence of the cannabinoid system as a promising therapeutic target. We highlight animal and human studies, including for instance, reports coming from Latin American laboratories on single nucleotide polymorphisms in stress-related genes and potential biomarkers of vulnerability to addiction, that aim to bridge the knowledge from basic science to clinical research.

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“…It should be noted that the same single nucleotide polymorphism in ABCB1 genes was found in Colombian patients with addictive behavior and addicted to heroin and cocaine. Then, it seems viable that genetics may contribute to the high frequency of tramadol use in patients with OAD [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Dependence to legally prescribed opioid analgesics in a university hospital in Medellin-Colombia: an observational study

Garcia-Orjuela

Alarcon-Franco

Sanchez-Fernandez

et al. 2016

BMC Pharmacol Toxicol

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BackgroundIn some countries the misuse and diversion of prescribed opioid analgesic is increasing considerably, but there is no official data regarding the situation in Colombia. The aim of this study was to identify all dependent to opioid analgesics legally prescribed patients that were treated in a University Hospital in Medellin, Colombia during 4 years and to characterize this population.MethodsObservational study in a University Hospital in Medellin, Colombia, searching for patients with ICD-10 codes related with opioid related disorders, adverse events or pain and treated between January 2011 and December 2014.ResultsSixty patients with opioid dependence according to DSM-IV criteria were found from 3332 clinical charts reviewed. The median age was 43 years. Although all patients met the DSM-IV criteria, 33 % of patients were wrongly diagnosed by other ICD-10 codes. Almost all patient (88 %) initiated opioids after medical prescription although the adherence to pain scale was low (25 %). The median time of consumption was 48 months. Tramadol was the opioid more frequently used by patients, followed by morphine and oxycodone. A statistically significant higher consumption of other psychotropic substances was observed in male than female (P = 0.005 by Fisher’s test). After be diagnosed, 55 % of patients gone a methadone-based replacement therapy.ConclusionLegally prescribed opioid dependence was belatedly diagnosed in 60 patients in a University hospital, after prolonged use of drugs to treat chronic pain and with low adherence to pain scale or guidelines. This is the first report in Colombia.

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Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine

Cited by 11 publications

References 23 publications

Influence of dopaminergic system gene polymorphisms on mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays

Influence of dopaminergic system gene polymorphisms on mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience

Dependence to legally prescribed opioid analgesics in a university hospital in Medellin-Colombia: an observational study

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