Genetic variants and normal tissue toxicity after radiotherapy: A systematic review

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice

“…Recent evidence indicates that interpatient variation in the development of side effects after cancer radiotherapy can not be explained, to a clinically relevant effect, by polymorphisms in individual candidate genes [31], therefore alternative approaches to investigating the genetic basis of radiotherapy side effects are needed [32]. One approach involves evaluating the whole genome, which allows the discovery of a priori unknown variants as associated with the trait, in the controlled environment of a model system.…”

Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma

“…XRCC1 and XRCC3 are two of the genes that are involved in DNA repair. The association of functional variants of these genes with radiation-induced late complications was previously investigated with inconsistent results (25). The majority of the published studies included breast and prostate cancer patients in Caucasian populations.…”

No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study

“…However, a recent study found no significant association between genotype and late clinical radiosensitivity in patients treated for gynaecological tumours [24]. A recent review of genetic variants and radiation toxicity included studies of the TGFB1 gene and highlighted the methodological issues involved [25]. The SNPs that have been studied in the TGFB1 gene include C-509T (rs1800469) and T+29C (rs1800470 encoding Leu10Pro; previously known as rs1982073), which are in strong linkage disequilibrium (LD) with each other such that the minor allele of C-509T (the T allele) and the minor C allele of L10P, encoding proline Pro10 tend to be inherited together.…”