Genetic variance contributes to naltrexone-induced inhibition of sucrose intake in inbred and outbred mouse strains

Dopamine D1 and opioid receptor antagonist-induced reductions of fructose and saccharin intake in BALB/c and SWR inbred mice

“…The solution was presented in a 10-ml plastic syringe fitted with a stainless steel sipper tube (Dym et al, 2007(Dym et al, , 2009(Dym et al, , 2010. Intakes were measured to the nearest 0.1 ml at 5, 15, 30, 60, 90, and 120 min, and then food and water rations were returned.…”

“…It is unknown whether these effects are due to differences in DA D1 receptor binding between these two strains. Whereas NTX moderately inhibited sucrose intake in BALB/c mice, it was ineffective in SWR mice (Dym et al, 2007). Conversely, NTX suppressed Intralipid intake in SWR, but not BALB/c mice (Dym et al, 2010).…”

“…Conversely, DA D1, but not D2 receptor mediation of fructose intake, has been demonstrated in rats with SCH, but not raclopride suppressing intake (Pritchett and Hajnal, 2011), but opioid receptor mediation of fructose intake is unknown. Therefore, the present study investigated whether DA D1 (SCH) and opioid (NTX) receptor antagonism altered intakes of fructose (8%) and saccharin (0.2%) solutions in these two inbred strains of mice over an identical dose range and time course as was performed for sucrose (Dym et al, 2007(Dym et al, , 2009 and Intralipid (Dym et al, 2010) intake.…”

“…Our laboratory found that marked strain differences occurred in the reduction of sucrose intake following NTX over a wide dose range (0.01-5 mg/kg) in eleven inbred strains (Dym et al, 2007), and following the DA D1 antagonist, SCH23390 (SCH), but not the DA D2 antagonist, raclopride, over a wide dose range (50-1600 nmol/kg) in eight inbred strains (Dym et al, 2009). Correspondingly, marked strain differences occurred in the reduction of fat (Intralipid) following NTX and SCH in 8 inbred strains (Dym et al, 2010).…”

A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment

“…During these sessions, motivation might have differentially affected behavior in BALB/cJ mice compared to C57BL/6J mice. BALB/cJ mice have previously been found to cumulatively consume more sucrose than C57BL/6J mice over a 2 h period [45]. In a behavioral chaining task, BALB/cJ mice responded more for sucrose pellets and task performance was sustained at a higher level over sessions than in C57BL/6J mice [46].…”