Genetic Variability within ADA Gene and Endometrium Cancer

Abstract

Adenosine Deaminase (ADA) is a polymorphic enzyme that degrades irreversibly adenosine to inosine and is present in cell cytoplasm and in interstitial fluid was it acts as ecto-ADA. Ecto-ADA shows also extra-enzymatic activity acting as co-stimulatory molecule of adenosine receptors .Adenosine is a purine nucleoside that hasan important role in cancer development.In solid tumors high level of this substance is determined by hypoxia resulting in inhibition of T cell killer activation .