Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review

The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders

“…Both APA datasets comprised of various human‐imprinted genes. DLGAP2 , which has been implicated in the development of autism (Nardone et al., 2014; Rasmussen, Rasmussen, & Silahtaroglu, 2017; Soler et al., 2018), was significantly hypomethylated in both our APA sperm and blastocyst groups. In addition, the cytoband classically responsible for Beckwith–Wiedemann syndrome (chr11p15.5) was significantly impacted in the APA sperm as well as the overlapping group of DMR‐associated genes.…”

Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm

“…Due to its important role in PSD signaling, even small changes in the expression of DLGAP2 can have severe consequences [26,32]. Of particular relevance, DLGAP2 has been linked to schizophrenia and importantly, has been identified as an autism candidate gene [27,28,33,34]. Differential methylation of DLGAP2 is reported in the brain of individuals with autism, and has been linked to posttraumatic stress disorder in rats [27,35].…”

“…DLGAP2, a membraneassociated protein located in the post-synaptic density of neurons, plays a key role in synapse organization and neuronal signaling [26]. Dysregulation of DLGAP2 is associated with various neurological and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia [26][27][28][29]. In our prior screen, we identified 17 differentially methylated CpG sites within DLGAP2 in the sperm of cannabis-exposed men compared to controls.…”

Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology

“…DLG1 participates in the trafficking of glutamate and aspartate receptors and α-subunits of the potassium channels Kv1.4 and Kv 4.2 to the cell membrane, all of which are crucial for basal synaptic transmission and synaptic plasticity (Gardoni et al, 2007;Fourie et al, 2014). Accordingly, there is mounting evidence that associates DLG1 deficiency or DLG1 mutant variants with the development of a number of neurological disorders ( Figure 1B) (Soler et al, 2018).…”