Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms

Favela-Mendoza, Alma Faviola; Rangel-Villalobos, Héctor; Fricke-Galindo, Ingrid; Ortega-Vázquez, Alberto; Martínez-Cortés, Gabriela; López-López, Marisol

doi:10.1007/s11033-018-4419-x

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…Although this association has been reported in other populations [16,[30][31][32], the genetic variability among different racial groups, and polymorphisms studies in particular populations, are relevant, with implications for drug response. To our knowledge, there is limited information regarding these polymorphisms and TAC concentration in Mexican KT patients [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Genetic variability in the Mexican population has been reported. Polymorphisms studies in particular populations are relevant, which could imply a diverse drug response, and there is limited information regarding these polymorphisms and TAC in Mexican KT patients [18,19]. Although the results vary depending on the population studied, genotyping could be useful for the dosing approach and therapeutic drug monitoring in the post-transplant phase [19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant

Alatorre-Moreno,

Saldaña-Cruz,

Pérez-Guerrero

et al. 2024

Genes

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Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after transplantation. This drug is transported from cells via P-glycoprotein (ABCB1) and is a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, particularly CYP3A4 and CYP3A5. Several single-nucleotide polymorphisms (SNPs) have been identified in the genes encoding CYP3A4, CYP3A5, and ABCB1, including CYP3A4-392A/G (rs2740574), CYP3A5 6986A/G (rs776746), and ABCB1 3435C/T (rs1045642). This study aims to evaluate the association among CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T polymorphisms and TAC, serum concentration, and biochemical parameters that may affect TAC pharmacokinetics in Mexican kidney transplant (KT) patients. Methods: Forty-six kidney transplant recipients (KTR) receiving immunosuppressive treatment with TAC in different combinations were included. CYP3A4, CYP3A5, and ABCB1 gene polymorphisms were genotyped using qPCR TaqMan. Serum TAC concentration (as measured) and intervening variables were assessed. Logistic regression analyses were performed at baseline and after one month to assess the extent of the association between the polymorphisms, intervening variables, and TAC concentration. Results: The GG genotype of CYP3A5-6986 A/G polymorphism is associated with TAC pharmacokinetic variability OR 4.35 (95%CI: 1.13–21.9; p = 0.0458) at one month of evolution; in multivariate logistic regression, CYP3A5-6986GG genotype OR 9.32 (95%CI: 1.54–93.08; p = 0.028) and the use of medications or drugs that increase serum TAC concentration OR 9.52 (95%CI: 1.79–88.23; p = 0.018) were strongly associated with TAC pharmacokinetic variability. Conclusion: The findings of this study of the Mexican population showed that CYP3A5-6986 A/G GG genotype is associated with a four-fold increase in the likelihood of encountering a TAC concentration of more than 15 ng/dL. The co-occurrence of the CYP3A5-6986GG genotype and the use of drugs that increase TAC concentration correlates with a nine-fold increased risk of experiencing a TAC at a level above 15 ng/mL. Therefore, these patients have an increased susceptibility to TAC-associated toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant

Alatorre-Moreno,

Saldaña-Cruz,

Pérez-Guerrero

et al. 2024

Genes

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“…Concerning storage resources and biological data management, respondents identified that the scientific community lacks a national information system or repository that coordinates efforts in a similar way to the base EBI in Europe, NCBI in the United States or like those in developing countries, like the Institute of Bioinformatics of India [9,39,40]. In Mexico, high-quality research is being currently carried out exploring Mexican biodiversity, such as the metagenome project in the Gulf of Mexico (CIGOM) [41] and in Cuatro Ciénegas [42], or other genomic studies of the Mexican population (including indigenous population) aimed to develop genomic medicine and pharmacogenomics [43][44][45]. Due to the generation of this mass of information, a national repository would facilitate access to Mexican biodiversity for the solution of national problems in sectors such as health and environment through bioinformatic studies.…”

Section: Build a Plan To Improve The Ict Infrastructure And Managementmentioning

confidence: 99%

Bioinformatics in Mexico: A diagnostic from the academic perspective and recommendations for a public policy

2020

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In this work, we present a diagnostic analysis of strengths, weaknesses, opportunities and threats (SWOT) of the current state of Bioinformatics in Mexico. We conducted semi-structured interviews among researchers and academics with key expertise in this field, identified by bibliometric analyses and qualitative sampling techniques. Additionally, an online survey was conducted reaching a higher number of respondents. Among the relevant findings of our study, the lack of specialized human resources and technological infrastructure stood out, along with deficiencies in the number and quality of academic programs, scarce public investment and a weak relationship between public and private institutions. However, there are great opportunities for developing a national Bioinformatics to support different economic sectors. In our opinion, this work could be useful to favor a comprehensive network among Mexican researchers, in order to lay the foundations of a national strategy towards a well designed public policy.

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“…These results suggest, to some degree, regional population continuity throughout the colonial period. Other recent studies have focused on genetic variation of mestizos primarily for the purpose of forensic investigations (Hughes, Algee-Hewitt, Reineke, Clausing, & Anderson, 2017;Martínez-Cortés et al, 2017) and implications for drug treatment response (Favela-Mendoza et al, 2018). Research carried out by INMEGEN has been criticized for creating a bias in genomic research resulting from excessively high public and government expectations, with a major goal of the work to accommodate postrevolutionary ideas of a Mexican citizen (Beltran, Garcia Deister, & Rios, 2014).…”

Section: Genetic and Related Bioarcheological Studiesmentioning

confidence: 99%

“…Recent genetic studies in Mexico have focused a great deal on genomic mapping of the mestizo population and evaluating the connection between national identity and genomic variation among indigenous Mexican groups regionally (Green, Derr, & Knight, ; Lopez Beltran & Vergara Silva, ; Moreno‐Estrada et al, ; Schwartz‐Marin & Silva‐Zolezzie, ; Silva‐Zolezzi, Hidalgo‐Miranda, & Estrada‐Gil, ). Much of this work has been carried out by Mexico's National Institute of Genomic Medicine (INMEGEN), with a major focus on improving health care through genomic research (Silva‐Zolezzi et al, ; Rubi‐Castellanos et al, ; Schwartz‐Marin & Silva‐Zolezzi, ; Lopez Beltran & Vergara Silva, ; Favela‐Mendoza et al, ). Some recent studies have detected a remarkably consistent pattern of geographic population variation in modern mestizos when compared with patterns of variation among precontact groups (Moreno‐Estrada et al, ; Rubi‐Castellanos et al, ; Silva‐Zolezzi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Changes in indigenous population structure in colonial Mexico City and Morelos

Ragsdale

Willermet

Edgar

2019

Intl J of Osteoarchaeology

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The Spanish conquest and colonization of Mexico had disastrous effects on indigenous people. Disease, coupled with drastic changes in the economic, political, and religious structures, led to an enormous depopulation event throughout the colony of New Spain. What remains unclear in historic and archeological accounts of Spanish colonization in Mexico is the effects of these changes on indigenous population structure and variation. In this study, we use biological distance and population structure analyses of two Mexico City church ossuary samples from the 16th to 17th centuries, as well as a sample of burials from a convent in nearby Morelos, to investigate these relationships at the center of the Spanish colony in Central Mexico. Colonial samples are compared with a large data set of precontact samples from Central Mexico and the surrounding regions, to evaluate changes in population structures. We compare colonial and precontact samples using biological distance analysis and a population structure program commonly applied in genetic analyses and modified for phenotypic data. Our results show that the colonial Mexico City samples are more biologically similar to the precontact samples from Veracruz, Toluca Valley, and West Mexico than to other precontact samples from the Valley of Mexico. The sample from Yecapixtla in Morelos is also most similar to the Veracruz, Toluca Valley, and West Mexico samples but is also somewhat similar to the precontact sample from Morelos and the nearby Oaxaca Valley. Generally, biological similarities among colonial samples and precontact samples do not correlate with geographic proximity or population size but coincide with cultural changes. Our study provides bioarcheological evidence of some degree of population replacement, resulting either from forced migration from surrounding areas for labor or through indigenous alliances with the Spanish conquerors. Our results also show concordance between traditional biodistance analysis and nontraditional analyses employed in population genetics studies.

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Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms

Cited by 8 publications

References 39 publications

Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant

Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant

Bioinformatics in Mexico: A diagnostic from the academic perspective and recommendations for a public policy

Changes in indigenous population structure in colonial Mexico City and Morelos

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