Genetic Tests To Evaluate Prognosis and Predict Therapeutic Response in Acute Myeloid Leukemia

Gulley, Margaret L.; Shea, Thomas C.; Fedoriw, Yuri

doi:10.2353/jmoldx.2010.090054

Cited by 44 publications

(43 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results showed an overall incidence of c-KIT mutation in 30.4% of cases, as previously reported in adult CBF AML (6), and a better prognosis for CBF AML than for cytogenetically normal or other subtypes of AML, which is in agreement with previous data (19,20). In our study, inv(16) AML had a significantly longer DFS than t(8;21) AML, consistent with previous reports demonstrating that patients with t(8;21) have significantly shorter survival times after relapse than patients with inv (16), possibly related to a lower response to salvage treatment in patients with t(8;21) (10,11,21).…”

Section: Discussionsupporting

confidence: 83%

Core binding factor acute myeloid leukaemia and c-KIT mutations

et al. 2013

View full text Add to dashboard Cite

Abstract. Core binding factor (CBF) acute myeloid leukaemia (AML) represents 5-8% of all AMLs and has a relatively favourable prognosis. However, activating c-KIT mutations are reported to be associated with higher risk of relapse and shorter survival. To verify the incidence and prognostic value of c-KIT mutations in CBF AML, we retrospectively analysed bone marrow samples of 23 consecutive adult patients with de novo CBF AML [14 inv(16) and 9 t(8;21)] treated at a single institution from 2000 to 2011. All patients received standard induction chemotherapy with cytarabine, idarubicin and etoposide; 13 underwent allogeneic stem cell transplantation. c-KIT mutations in exons 8, 9, 10, 11, 13, 14 and 17 were assessed by PCR amplification in combination with direct sequencing. c-KIT mutations (3 in exon 10 and 4 in exon 17) were detected in 7/23 (30.4%) patients, 3 with t(8;21) and 4 with inv(16). No difference in c-KIT mutation status was observed between cases with inv(16) or t(8;21) alone and cases with additional cytogenetic abnormalities. No association between gender, age, white blood cell and platelet count, peripheral blood and bone marrow blast cells at diagnosis, achievement of complete remission, cytogenetic risk groups and Wilms tumour gene 1 (WT1) levels was found. On the contrary, lactate dehydrogenase (LDH) values were higher in mutated than in non-mutated patients (P=0.01). Overall survival (OS) rates were longer in CBF compared to the other types of AML and disease-free survival (DFS) was longer in inv(16) than in t(8;21) AML. OS and DFS were similar in mutated and non-mutated CBF AML patients. Our results confirm a better prognosis for CBF AML than all other AML categories, and for inv(16) than t(8;21) AML. However, no prognostic value for c-KIT mutational status was found in our series. The association between LDH levels and c-KIT mutation would indicate a more active proliferation for mutated CBF AML.

show abstract

Section: Discussionsupporting

confidence: 83%

Core binding factor acute myeloid leukaemia and c-KIT mutations

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Many hematopoietic malignancies were found to be clonally aneuploid, with an identifiable karyotype that carries a prognostic value (7)(8)(9)(10). Furthermore, individuals with constitutional global aneuploidy, such as those with Down syndrome, mosaic variegated aneuploidy, and Turner syndrome, are found to exhibit increased rates of malignancies (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Chromosomal instability and cancer: a complex relationship with therapeutic potential

Bakhoum¹,

Compton²

2012

J. Clin. Invest.

221

191

View full text Add to dashboard Cite

“…Być może wraz z wprowadzeniem nowych technik jednoczesnego monitorowania wielu defektów molekularnych ocena ich wpływu na rokowanie będzie możliwa. Największe nadzieje w tym zakresie budzą wyniki prac nad diagnostycznym wykorzystaniem profilowania ekspresji genów (w tym WT1, BAALC, ERG, miRNA-223 i innych) [54,55].…”

Section: Znaczenie Rokownicze Cebpa W Ostrej Białaczce Szpikowejunclassified

“…Genotypy rokujące niekorzystnie oznaczono symbolem . Na podstawie [30,37,48,52,55]. Przez znak (+) i (-) rozumie się odpowiednio obecność lub brak mutacji danego genu.…”

Section: Znaczenie Rokownicze Cebpa W Ostrej Białaczce Szpikowejunclassified

Prognostic significance of CEBPA gene mutations in patients with acute myeloid leukemia

Pieronkiewicz¹,

Lewandowski²

2010

View full text Add to dashboard Cite

Genetic Tests To Evaluate Prognosis and Predict Therapeutic Response in Acute Myeloid Leukemia

Abstract: Management of patients with acute myeloid leukemia relies on genetic tests that inform diagnosis and

Cited by 44 publications

References 109 publications

Core binding factor acute myeloid leukaemia and c-KIT mutations

Core binding factor acute myeloid leukaemia and c-KIT mutations

Chromosomal instability and cancer: a complex relationship with therapeutic potential

Prognostic significance of CEBPA gene mutations in patients with acute myeloid leukemia

Contact Info

Product

Resources

About