Genetic testing for heart disease susceptibility: potential impact on motivation to quit smoking

Sanderson, Saskia C.; Michie, Susan

doi:10.1111/j.1399-0004.2007.00810.x

Cited by 44 publications

(38 citation statements)

References 26 publications

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“…For those who underwent genetic testing for diabetes, myocardial infarction, and cancer, there has been little or no effect on longterm abstinence of smoking or short-term changes in diet and exercise. 22,28,32 There are concerns that negative genetic test results for CVD may lead to false reassurance, while positive results may induce unnecessary anxiety in others. 33 In this study, the false reassurance was identified but not related to above-average results.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

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Introducing genetic testing for cardiovascular disease in primary care: a qualitative study

et al. 2014

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BackgroundWhile primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these new sources of risk information. AimTo explore how patients who have had a recent conventional cardiovascular risk assessment, perceive additional information from genetic testing for CHD. Design and settingQualitative interview study in 12 practices in Nottinghamshire from both urban and rural settings. MethodInterviews were conducted with 29 adults, who consented to genetic testing after having had a conventional cardiovascular risk assessment. ResultsIndividuals' principal motivation for genetic testing was their family history of CHD and a desire to convey the results to their children. After testing, however, there was limited recall of genetic test results and scepticism about the value of informing their children. Participants dealt with conflicting findings from the genetic test, family history, and conventional assessment by either focusing on genetic risk or environmental lifestyle factors. In some participants, genetic test results appeared to reinforce healthy behaviour but others were falsely reassured, despite having an 'aboveaverage' conventional cardiovascular risk score. ConclusionAlthough genetic testing was acceptable, participants were unclear how to interpret genetic risk results. To facilitate healthy behaviour, health professionals should explore patients' understanding of genetic test results in light of their family history and conventional risk assessment. Keywordscoronary heart disease; family practice; genetic testing; primary health care.

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Section: Comparison With Existing Literaturementioning

confidence: 99%

“…[23][24][25][26][27] Participants' opinions have also been ascertained in hypothetical scenarios. 28,29 In this study, a perceived familial risk of CHD was a major driver for requesting genetic testing. This parallels the findings in studies of heart disease and breast cancer in secondary care.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study

et al. 2014

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“…We utilized a common vignette paradigm that asks individuals to consider different hypothetical scenarios for genetic testing. [21][22][23] …”

Section: Introductionmentioning

confidence: 99%

Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study

Rennie

Stinge

King

et al. 2011

Eye

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Aims Smoking can increase the risk of macular degeneration and this is more than additive if a person also has a genetic risk. The purpose of this study was to examine whether knowledge of genetic risk for age-related macular degeneration (AMD) could influence motivation to quit smoking. Methods A questionnaire-based study of hypothetical case scenarios given to 49 smokers without AMD. Participants were randomly allocated to a generic risk, high genetic risk, or low genetic risk of developing AMD scenario. Results Forty-seven percent knew of the link between smoking and eye disease. In all, 76%, 67%, and 46% for the high risk, generic, and low risk groups, respectively, would rethink quitting (P for trend ¼ 0.082). In all, 67%, 40%, and 38.5%, respectively, would be likely, very likely, or would definitely quit in the following month (P for trend ¼ 0.023). Few participants (o16% of any group) were very likely to or would definitely attend a quit smoking session with no difference across groups. In all, 75.5% of participants would consider taking a genetic test for AMD. Conclusion In this pilot study, a trend was seen for the group given high genetic risk information to be more likely to quit than the generic or low genetic risk groups. Participants were willing to take a genetic test but further work is needed to address the cost benefits of routine genetic testing for risk of AMD. More generic risk information should be given to the public, and health warnings on cigarette packets that 'smoking causes blindness' is a good way to achieve this.

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“…Two analog studies were published by Sanderson and coworkers (2005;Sanderson and Michie 2007) analyzing hypothetical smoking cessation rates and attitudes towards smoking behavior. In the study by Sanderson and Michie (2007) addressing genetic testing for heart disease susceptibility, 261 smokers were randomized into three groups.…”

Section: Smoking Cessationmentioning

confidence: 99%

“…In the study by Sanderson and Michie (2007) addressing genetic testing for heart disease susceptibility, 261 smokers were randomized into three groups. Of the participants, 96 received a genetic high-risk result for heart disease and 79 a genetic low-risk result for heart disease.…”

Section: Smoking Cessationmentioning

confidence: 99%

Patient compliance based on genetic medicine: a literature review

Schneider

Schmidtke

2013

J Community Genet

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For this literature review, medical literature data bases were searched for studies on patient compliance after genetic risk assessment. The review focused on conditions where secondary or tertiary preventive options exist, namely cancer syndromes (BRCA-related cancer, HNPCC/colon cancer), hemochromatosis, thrombophilia, smoking cessation, and obesity. As a counterpart, patient compliance was assessed regarding medication adherence and medical advice in some of the most epidemiologically important conditions (including high blood pressure, metabolic syndrome, and coronary heart disease) after receiving medical advice based on nongenetic risk information or a combination of genetic and nongenetic risk information. In the majority of studies based on genetic risk assessments, patients were confronted with predictive rather than diagnostic genetic profiles. Most of the studies started from a knowledge base around 10 years ago when DNA testing was at an early stage, limited in scope and specificity, and costly. The major result is that overall compliance of patients after receiving a high-risk estimate from genetic testing for a given condition is high. However, significant behavior change does not take place just because the analyte is "genetic." Many more factors play a role in the complex process of behavioral tuning. Without adequate counseling and guidance, patients may interpret risk estimates of predictive genetic testing with an increase in fear and anxiety.

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Genetic testing for heart disease susceptibility: potential impact on motivation to quit smoking

Cited by 44 publications

References 26 publications

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study

Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study

Patient compliance based on genetic medicine: a literature review

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