Genetic Targets and Applications of Iron Chelators for Neurodegeneration with Brain Iron Accumulation
Neharika Marupudi,
May P. Xiong
Abstract:Neurodegeneration with brain iron accumulation (NBIA)
is a group
of neurodegenerative diseases that are typically caused by a monogenetic
mutation, leading to development of disordered movement symptoms such
as dystonia, hyperreflexia, etc. Brain iron accumulation can be diagnosed
through MRI imaging and is hypothesized to be the cause of oxidative
stress, leading to the degeneration of brain tissue. There are four
main types of NBIA: pantothenate kinase-associated neurodegeneration
(PKAN), PLA2G6-associated n… Show more
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