Genetic synergy between
Acinetobacter baumannii
undecaprenyl phosphate biosynthesis and the Mla system impacts cell envelope and antimicrobial resistance
Hannah R. Noel,
Sowmya Keerthi,
Xiaomei Ren
et al.
Abstract:Acinetobacter baumannii
is a Gram-negative bacterial pathogen that poses a major health concern due to increasing multidrug resistance. The Gram-negative cell envelope is a key barrier to antimicrobial entry and includes an inner and outer membrane. The maintenance of lipid asymmetry (Mla) system is the main homeostatic mechanism by which Gram-negative bacteria maintain outer membrane asymmetry. Loss of the Mla system in
A. baumannii
results in attenuated virulence and… Show more
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