Genetic susceptibility variants for chronic lymphocytic leukaemia in Mexican mestizos

Hernandez-Caballero, Alvaro; Arellano-Llamas, Abril; Cruz-Rico, Jorge; Ojeda, Jorge Vela; Tuna-Aguilar, Elena; Aguayo-González, Álvaro; Oropeza-Martínez, M Patricia; Montiel‐Cervantes, Laura; Anaya, Luis; Canizales‐Quinteros, Samuel; Majluf‐Cruz, Abraham

doi:10.1111/bjh.13259

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Chronic Lymphocytic Leukemia CLL is the most common leukemia in countries with a predominantly Caucasian population [41]; however, it is very rare in Asia and Latin America, including Mexico [13,42,43]. In Western countries CLL accounts for approximately 30% of all leukemias, in contrast to less than 7% among Mexican mestizos [4] (Fig.…”

Section: Myeloproliferative Neoplasiasmentioning

confidence: 99%

“…1). Some minor allele frequency differences have been observed in Mexican mestizos in contrast to the Caucasian population; however, the underlying causes for geographic variations have never been completely clarified [41]. In addition to these possible genetic differences, infectious, occupational, environmental, and genetic factors have all been suggested as other potential contributors [4].…”

Section: Myeloproliferative Neoplasiasmentioning

confidence: 99%

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Geographic Hematology: Some Observations in Mexico

et al. 2018

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In 1963 Jean Bernard introduced the concept of “geographic hematology” and distinguished 2 branches, i.e., “ethnic hematology,” which deals with differences between populations, and “environmental hematology,” which considers factors such as food habits, infections, and others. Both of these branches have implications in the distribution of hematological diseases worldwide. In comparison with Caucasian populations, in Mexico a significantly higher prevalence of acute lymphoblastic, acute promyelocytic, and acute megakaryoblastic leukemias has been described. The rate of chronic myeloid leukemia seems to be as high as that reported in Caucasian populations, while other myeloproliferative neoplasias are significantly less frequent in Mexico. Significantly lower prevalences of hairy cell leukemia, chronic lymphocytic leukemia, multiple myeloma, and Waldenström’s macroglobulinemia have been reported from Mexico. Regrettably, the influence of drug companies interested in selling their new and expensive drugs has resulted in both overdiagnosis of some diseases and overidentification of the refractory forms of some of these conditions to justify the use of unnecessary drugs.

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Section: Myeloproliferative Neoplasiasmentioning

confidence: 99%

Section: Myeloproliferative Neoplasiasmentioning

confidence: 99%

Geographic Hematology: Some Observations in Mexico

et al. 2018

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“…Research has shown that the NHW population has a higher incidence of CLL compared with Hispanics (Nabhan et al, 2014). Therefore, biological differences in disease presentation could render minority groups less responsive to therapies that are confirmed only in non-Hispanic groups (Bencomo-Alvarez et al, 2020;Di Bernardo et al, 2008;Hernandez-Caballero et al, 2015;Slager et al, 2010). In a large population-based study, Nabhan et al demonstrated that CLL is indeed more prevalent in NHWs, with more than 85% of all cases reported over 15 years, followed by Black (6.8%), Hispanic (4.9%), and Asian (2.8%) populations (Nabhan et al, 2014).…”

Section: Chronic Lymphoblastic Leukemia (Cll)mentioning

confidence: 99%

Blood cancer health disparities in the United States Hispanic population

Bencomo‐Alvarez

Rubio

Gonzalez

et al. 2021

Cold Spring Harb Mol Case Stud

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Cancer is a challenging, multifaceted disease that involves a combination of biological and non-biological factors. Aside from COVID-19, cancer is the second leading cause of death in the United States (U.S.), and the first among Hispanic Americans. The Hispanic population is the largest minority group in the U.S., which is rapidly growing in size. Unfortunately, U.S. Hispanics and other minority groups experience many different health disparities, resulting in poor survival outcomes and a reduced quality of life. Factors such as genomic mutations, lower socioeconomic status, lack of education, reduced access to health care, comorbidities, and environmental factors all contribute to these health care inequalities. In the context of blood cancer health disparities, Hispanic patients are often diagnosed at a younger age and have worse outcomes compared with non-Hispanic individuals. In the present article, we highlight the existing knowledge about cancer health disparities in the Hispanic population, with a focus on chronic and acute leukemia. In our experience at the U.S./Mexico border, analysis of several different blood cancers demonstrated that younger Hispanic patients with acute lymphoid or myeloid leukemia have higher incidence rates and worse prognoses. A combined approach, involving improved health care access and better knowledge of the underlying factors, will allow for more timely diagnoses and the development of intervention strategies aimed at reducing or eliminating the disparities.

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Genetic susceptibility variants for chronic lymphocytic leukaemia in Mexican mestizos

Cited by 2 publications

References 8 publications

Geographic Hematology: Some Observations in Mexico

Geographic Hematology: Some Observations in Mexico

Blood cancer health disparities in the United States Hispanic population

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