Genetic susceptibility to simple febrile seizures: Interleukin-1β promoter polymorphisms are associated with sporadic cases

Association study between interleukin 1β gene and epileptic disorders: a HuGe review and meta-analysis

“…10 Results of HWE analysis for controls were reported in four studies. 10,14,40,44 Our calculation of HWE for the rest of included studies showed that one report deviated from HWE. 41 In all studies, investigators used the same DNA genotyping method.…”

“…10,13,40,44 The quality of studies ranged from 0 to 8, out of a possible score of 10. Five studies were conducted in Asia, 8,11,14,39,42 seven in Europe, 9,13,38,40,41,43,44 and one in the USA. 10 Results of HWE analysis for controls were reported in four studies.…”

Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis

“…FS, the most common type of epileptic seizures in early life world wide (Nakayama and Arinami, 2006;Kundu et al, 2012;Salzmann et al, 2012), is a matter of concern to pediatricians with a total prevalence of 3%-7% in children up to 7 years (Cross, 2012) and a cumulative incidence of 2%-5% in the first 5 years of life (Verity et al, 1985;Visser et al, 2012). FS, occurring during rapid rising of fever (Özaydın et al, 2012) between 6 months and 5 years of age (Klein et al, 2012;Kumari et al, 2012;Martinos et al, 2012;Teran et al, 2012;Zareifar et al, 2012), can be divided into simple forms (only occuring once in 24 h, generalized, and duration < 15 min) and complex forms (recurrent during 24 h, focal, and duration > 15 min) (Kira et al, 2005;Abdel Rasol et al, 2012;French, 2012;Offringa and Newton, 2013;Sasidaran et al, 2012;Scott et al, 2012;Yu et al, 2012).…”

Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis

“…Histopathology of human epileptic hippocampi shows a specific neuronal loss in the areas of CA and gliosis (1). Formerly, the relationship between prolonged febrile seizures (FS) and the development of MTLE has been shown with regard to cytokine gene expression (2), although other studies have failed to replicate it (3,4,5). Because altered immunity due to the etiopathogenesis of HS has been a point of interest, the role of proinflammatory cytokines and growth factors in the signaling process leading to a glial reaction have been investigated in animal models and human epilepsy (2,6,7,8).…”