Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis: How Far Is Our Understanding?

Żeber‐Lubecka, Natalia; Hennig, Ewa E.

doi:10.3389/fimmu.2021.606620

Cited by 18 publications

(7 citation statements)

References 298 publications

(364 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, except for its correlation with the renin-angiotensin system, little is known about its function. Of note, several studies consistently associated AOPEP with polycystic ovary syndrome (PCOS) [48][49][50][51][52][53].…”

Section: Analysis Of Single Snpsmentioning

confidence: 99%

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Lybech

Calabrò

Briuglia

et al. 2021

Genes

View full text Add to dashboard Cite

Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic component. In the present contribution we analyzed a sample of BD individuals (from STEP-BD database) to identify the genetic variants potentially associated with three different suicide-related phenotypes: 1) a feeling that the life was not worth living; 2) fantasies about committing a violent suicide; 3) previous attempted suicide. The sample under analysis included 1115 BD individuals. None of the SNPs reached genome-wide significance. However, a trend of association was evidenced for rs2767403, an intron variant of AOPEP gene, in association with phenotype #1 (p = 5.977 × 10−6). The molecular pathway analysis showed a significant enrichment in all the investigated phenotypes on pathways related to post synaptic signaling, neurotransmission and neurodevelopment. Further, NOTCH signaling or the γ-aminobutyric acid (GABA) -ergic signaling were found to be associated with specific suicide-related phenotypes. The present investigation contributes to the hypothesis that the genetic architecture of suicide behaviors in BD is related to alteration of entire pathways rather than single genes. In particular, our molecular pathway analysis points on some specific molecular events that could be the focus of further research in this field.

show abstract

Section: Analysis Of Single Snpsmentioning

confidence: 99%

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Lybech

Calabrò

Briuglia

et al. 2021

Genes

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence suggests an association between thyroid autoimmunity, obesity and cardiometabolic risk factors ( 8 – 10 ), whereas, elevated thyroid autoantibodies have been observed in an average of 22.3% of patients with PCOS compared with an average of 8.5% in healthy women ( 11 ). PCOS is a heterogeneous endocrine disorder affecting 5%–20% of women of reproductive age worldwide ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is characterized mainly by clinical and/or biochemical hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology and is associated with multiple metabolic aberrations, including insulin resistance and hyperinsulinemia, an increased risk of glucose intolerance and type 2 diabetes mellitus, dyslipidemia, hypertension, and endothelial dysfunction, independent of body mass index (BMI) ( 12 , 13 ). It has been speculated that the combination of PCOS with AT, even in the euthyroid state, may be associated with more pronounced metabolic derangements than either of these conditions alone, although an underlying mechanism has not been defined ( 11 , 14 – 16 ).…”

Section: Introductionmentioning

confidence: 99%

High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche

et al. 2023

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA). We also aimed to identify the clinical, metabolic, and endocrine profile of girls with AT and concurrent PA and compare them to girls with AT without PA, PA alone and healthy controls.MethodsNinety-one prepubertal girls aged 5–10 years, who attended our department for AT, PA and normal variants of growth and puberty were recruited for the study: 73 girls had PA, 6 AT without PA and 12 were referred for investigation of growth. All girls underwent clinical examination, detailed biochemical and hormonal screen. Standard dose Synachten stimulation test (SDSST) and oral glucose tolerance test (OGTT) were performed in all girls with PA. The whole study population was divided in 4 groups: Group PA−/AT+ included 6 girls with AT without PA; Group PA+/AT− PA subjects without AT; Group PA+/AT+ girls with PA and concomitant AT; Group PA-/AT- twelve healthy girls without PA nor AT (controls).ResultsAmong 73 girls presenting with PA 19 had AT (26%). BMI, systolic blood pressure (SBP) and the presence of goiter significantly differed between the four groups (p = 0.016, p = 0.022 and p < 0.001, respectively). When comparing hormonal parameters among the four groups significant differences were found in leptin (p = 0.007), TSH (p = 0.044), anti-TPO (p = 0.002), anti-TG (p = 0.044), IGF-BP1 (p = 0.006), Δ4-Α (p = 0.01), DHEA-S (p = <0.001), IGF-1 (p = 0.012) and IGF-BP3 (p = 0.049) levels. TSH levels were significantly higher in Group PA+/AT+ compared to PA+/AT− and PA−/AT− (p = 0.043 and p = 0.016, respectively). Moreover, girls with AT (Groups PA−/AT+ and PA+/AT+) had higher TSH levels than those in Group PA+/AT- (p = 0.025). Girls in Group PA+/AT + showed higher cortisol response at 60 min post-SDSST than girls in Group PA+/AT− (p = 0.035). During the OGTT, insulin concentrations at 60 min were significantly higher in Group PA+/AT + compared to Group PA+/AT− (p = 0.042).ConclusionA high frequency of AT among euthyroid prepubertal girls with PA was observed. The combination of PA with AT even in euthyroid state may be associated with a greater degree of insulin resistance, than PA alone.

show abstract

“…The syndrome may also be accompanied by other endocrine and metabolic disorders, contributing to an increased risk of endometrial cancer, obesity, diabetes, hypertension, dyslipidemia, and cardiovascular diseases [ 10 , 11 ]. Studies conducted in recent years also suggest a higher incidence of thyroid diseases, including subclinical hypothyroidism (SCH) [ 12 , 13 ] and autoimmune thyroiditis (AIT) [ 14 ] in women with PCOS, pointing out possible common etiology [ 15 , 16 ]. AIT, called Hashimoto thyroiditis (HT), affecting 5–20% of women of childbearing age, is one of the most common causes of hypothyroidism in areas with sufficient iodine content.…”

Section: Introductionmentioning

confidence: 99%

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Gawron

Baran

Derbisz

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) often coexist, but implications of the co-occurrence of two disorders have not yet been established. The objective is to conclude whether SCH with present or absent anti-thyroid antibodies (ATA) impacts on the PCOS phenotype and alters biochemical or clinical parameters. Methods: A retrospective cohort study was conducted in a tertiary reference center. Clinical and biochemical parameters of women with PCOS were analyzed. Results: A total of 367 women with PCOS were included in the study, 114 (31.1%) of whom were diagnosed with SCH and 16 (4.4%) with autoimmune thyroiditis (AIT). Among all parameters studied, the strongest relationship with SCH was confirmed for insulin resistance and dyslipidemia. SCH was an independent risk factor for insulin resistance. In SCH the additional presence of ATA did not exacerbate the metabolic disorders. There was no significant association of any PCOS phenotype with SCH, nor with the presence of circulating ATA. There was no significant difference in hormonal parameters and mFerriman–Gallwey scale score between women with PCOS with and without SCH. Conclusions: SCH alters metabolic, but not hormonal, parameters in PCOS. The diagnosis of SCH does not exclude the diagnosis of PCOS. The potential effect of positive ATA was insignificant.

show abstract

Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis: How Far Is Our Understanding?

Cited by 18 publications

References 298 publications

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Contact Info

Product

Resources

About