Genetic susceptibility, birth weight and obesity risk in young Chinese

Hong, Jing; Shi, Juan; Qi, Lü; Cui, Bin; Gu, Weiqiong; Zhang, Y; Li, L; Xu, Min; Wang, L; Zhai, Ying; Ma, Lin; Wang, R; Bi, Yufang; Wang, W; Ning, Guang

doi:10.1038/ijo.2012.87

Cited by 37 publications

(33 citation statements)

References 27 publications

(26 reference statements)

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“…The majority of previous studies are focused on populations of European Ancestry and adults. Subsequent studies have attempted to identify the associations in Chinese population, however, the results of GNPDA2, KCTD15, NEGR1, MC4R, SEC16B and ETV5 are inconsistent (Cheung et al, 2010;Wang et al, 2012;Hong et al, 2013;Xi et al, 2013). In addition, ten other obesity-related genes (LYPLAL1, MSRA, TFAP2B, MAP2K5, RPL27A, PAX5, CDKAL1, AMD1, HOXB5 and OLFM4) have not been examined in Chinese children.…”

Section: Introductionmentioning

confidence: 87%

Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population

Zhang

Wang

et al. 2015

Gene

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Section: Introductionmentioning

confidence: 87%

Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population

Zhang

Wang

et al. 2015

Gene

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“…Evidence also suggests that birth weight may modify genetic susceptibility towards weight gain and future obesity risk. 63 Modifying nutritional factors connected with parental feeding behaviours in infancy are primarily associated with breastfeeding and weaning. We found in a meta-analysis of 10 prospective studies that breastfeeding anytime in the first year life reduced the adjusted odds of overweight in childhood by 15% compared with not breastfeeding.…”

Section: Explanation Of Findingsmentioning

confidence: 99%

Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy

et al. 2012

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ObjectiveTo determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention.DesignSystematic review and meta-analysis.Search strategyElectronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts.Eligibility criteriaProspective observational studies following up children from birth for at least 2 years.ResultsThirty prospective studies were identified. Significant and strong independent associations with childhood overweight were identified for maternal pre-pregnancy overweight, high infant birth weight and rapid weight gain during the first year of life. Meta-analysis comparing breastfed with non-breastfed infants found a 15% decrease (95% CI 0.74 to 0.99; I2=73.3%; n=10) in the odds of childhood overweight. For children of mothers smoking during pregnancy there was a 47% increase (95% CI 1.26 to 1.73; I2=47.5%; n=7) in the odds of childhood overweight. There was some evidence associating early introduction of solid foods and childhood overweight. There was conflicting evidence for duration of breastfeeding, socioeconomic status at birth, parity and maternal marital status at birth. No association with childhood overweight was found for maternal age or education at birth, maternal depression or infant ethnicity. There was inconclusive evidence for delivery type, gestational weight gain, maternal postpartum weight loss and ‘fussy’ infant temperament due to the limited number of studies.ConclusionsSeveral risk factors for both overweight and obesity in childhood are identifiable during infancy. Future research needs to focus on whether it is clinically feasible for healthcare professionals to identify infants at greatest risk.

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“…However, it is not consistent in Chinese population. Despite some studies showed evidence of significant association (Shi et al [7] and Huang et al [15] in adults; Hong et al [16] in young, Wu et al [8] in children), studies by Cheung et al [17] and Tao et al [18] in adults, Wang et al [19] in children revealed non-significant association.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents

Song

Wang

et al. 2017

PLoS ONE

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Effects of MC4R variants in previous Chinese population studies were inconsistent. Gene-environment interactions might influence the effect of MC4R variants on obesity, which was still unclear. We performed the study to clarify the association of variants near MC4R gene with obesity-related phenotypes and gene-environment interactions in Chinese children and adolescents. Two common variants (rs12970134 and rs17782313) near MC4R were genotyped in 2179 children and adolescents aged 7–18 years in Beijing of China. Associations between the variants and obesity-related phenotypes together with gene-environment interactions were analyzed. The A-alleles of rs12970134 were nominally associated with risk of overweight/obesity (Odds Ratios (OR) = 1.21, 95%CI: 1.03–1.44, P = 0.025) and BMI (β = 0.33 kg/m2, 95%CI: 0.02–0.63, P = 0.025), respectively. The rs12970134 was also associated with HDL-C (β = -0.03mmol/L per A-allele, 95%CI: -0.05, -0.01, P = 0.013) independent of BMI. In the further analysis, we found the significant interaction of rs12970134 and physical activity/sedentary behaviors on BMI (Pinteraction = 0.043). The rs12970134 was found to be associated with BMI only in children with physical activity<1h/d and sedentary behaviors ≥2h/d (BMI: β = 1.27 kg/m2, 95%CI: 0.10–2.45, P = 0.034). The association was not detected in their counterparts with physical activity≥1h/d or sedentary behaviors <2h/d. We identified the effect of MC4R rs12970134 on overweight/obesity and BMI, and we also found physical activity and sedentary behaviors modified the association between the rs12970134 and BMI in Chinese children and adolescents.

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Genetic susceptibility, birth weight and obesity risk in young Chinese

Abstract: We confirmed the associations of the single-nucleotide polymorphism tagging six loci reported in recent GWAS with obesity in young Chinese. Our data also suggest birth weight may significantly modify genetic susceptibility to obesity risk.

Cited by 37 publications

References 27 publications

Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population

Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population

Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy

Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents

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