Genetic support of the causal association between gut microbiota and peripheral artery disease: a bidirectional Mendelian randomization study

Abstract

Background: The causal relationship between gut microbiota and peripheral artery disease (PAD) is still not clear. In this research, we employed the Mendelian randomization (MR) technique to explore the potential causal connection between 211 gut microbiota species and PAD. We also investigated whether the causal effects operate in both directions. Methods: We used Genome-wide Association Studies (GWAS) summary statistics data from the MiBioGen and FinnGen consortia to conduct a two-sample MR analysis to explore the causal link between gut microbiota and PAD. Sensitivity analysis is conducted to assess the robustness of the MR results. In addition to that, reverse MR analysis was performed to examine the inverse causal relationship. Results: The inverse variance weighted (IVW) method provided evidence supporting a causal relationship between 9 specific gut microbiota taxa and PAD. The study findings indicated that family Family XI (OR=1.

Causal associations of gut microbiota and pulmonary tuberculosis: a two-sample Mendelian randomization study

“…Meanwhile, Dorea is associated with autism spectrum disorder (ASD) ( Li Z. et al, 2023 ), inflammatory bowel disease (IBD) ( Zhang et al, 2021 ), hypertensive disorders in pregnancy (HDP) ( Wu et al, 2023a ), polycystic ovary syndrome (PCOS) ( Min et al, 2023 ), hemorrhagic stroke ( Shen et al, 2023 ), age-related macular degeneration (AMD) ( Li and Lu, 2023 ), nicotine dependence ( Chen Y. et al, 2023 ), and insomnia ( Li Z. et al, 2023 ). Similarly, Lachnochlostrium is linked to multiple diseases, including Alzheimer’s disease (AD) ( Ning et al, 2022 ), nonalcoholic fatty liver disease (NAFLD) ( Zhang et al, 2023 ), myasthenia gravis ( Su et al, 2023 ), type 2 diabetes ( Li and Li, 2023 ), gestational diabetes mellitus ( Wu et al, 2023b ), renal cell cancer ( Yin et al, 2023 ), insomnia ( Li Z. et al, 2023 ), peripheral artery disease ( Shi et al, 2024 ), peripheral atherosclerosis ( Jiang et al, 2023 ), Primary open-angle glaucoma (POAG) ( Zhou et al, 2024 ), and intervertebral disc degeneration ( Zheng et al, 2023 ). These studies demonstrate a causal association between gut microbiota and diseases.…”