GENETIC STUDY OF HEMOGLOBIN VARIANTS IN MICE (<i>MUS MUSCULUS</i>)

Genetic analysis of mutants in mice induced by N-ethyl-N-nitrosourea.

“…One of the mutants was observed as a change in the mobility of the bands on electrophoresis (Murota et al 1982) . The mobility of the bands was similar to that of Pon which carrier Hbb alleles under homozygous conditions (Watanabe et al 1976). In the second mutant, new bands were observed.…”

GEOGRAPHICAL DISTRIBUTION OF <i>Hbb^p</i> ALLELE IN THE JAPANESE WILD MOUSE, <i>MUS MUSCULUS MOLOSSINUS</i>

“…Therefore, there appears to be a close relationship between M, m. molossinus and other Asian house mouse subspecies (Watanabe et al 1976;Mizuno et al 1977;Morton and Tobin 1977).…”

“…The fact that Hbbp is commonly observed and HbbB is not in the Japanese wild mice may indicate a significant difference between the Japanese population and the Western Hemisphere populations whose Hbb alleles are predominantly Hbbd and Hbbe Selander et al 1969 a, b;Berry and Murphy 1970;Wheeler and Selander 1972 originated from Asian mouse also carried Hbbp allele would suggest the close relationship between M. m. molossinus and other Asian house mouse subspecies (Watanabe et al 1976;Mizuno et al 1977;Morton and Tobin 1977). This agrees well with Marshall's classification of Mus which divides Mus musculus in two groups, musculus group (mainly European subspecies) and castaneus group (Asian subspecies) (Marshall 1977).…”

“…For ~rst:ance, the HbbB allele is limited to the Western Hemisphere mice and laboratory strains related to C57B1 whereas the Hbb' allele has universal distribution Wheeler and Selander 1972;Staats 1976). The Hbbp allele seems to be common in Asian wild mice, Mus musculus castaneus, and M. m. molossinus, and several inbred strains originating from such Asian mice as M. m. molossinus, M. m. bactrianus, and certain lines of pet mice (Gilman 1974;Watanabe et al 1976;Morton and Tobin 1977;.…”

Three trypsinogens from rat pancreas

“…under the same conditions. Tryptic and chymotryptic activities were determined by the spectrophotometric method in [ 1,7]. To estimate the Mr-values of each trypsinogen by gel filtration, fractions with high amounts of trypsinogen were pooled and precipitated by addition of ammonium sulfate to 70% saturation.…”