Genetic studies on the Gc subtypes

Abstract

Gc subtypes were determined by immunofixation isoelectric focusing. In a family study involving 93 families with a total of 176 children, a three-allele model with six genotypes was confirmed. The distribution of Gc subtypes was studied in three populations from Europe and in a sample of Druzes from Northern Israel. Three new variant Gc types were observed.

Distribution of the Gc (Group‐specific Component) Subtypes in Cord Bloods and Blood Donors

“…The first routine separation of GC 1 into the subtypes GC IF and GC IS suitable for population surveys was achieved by isoelectric focusing (IEF) (Constans and Viau, 1977;Constans et ai, 1978), although the existence of GC 1 subtypes was first suspected much earlier (Ruoslahti, 1965). Family studies have confirmed that GC*IS and GC*JF are inherited as autosomal codominant alleles (Cleve et al, 1978;Kuhnl, Spielman and Loa, 1978). To date 36 GC variants have been described (Cleve et ai, 1981) and a system of nomenclature established for the naming of new variants (Constans and Cleve, 1979).…”

The distribution of transferrin, group-specific component and phosphoglucomutase-1 subtypes among the Lepchas of Darjeeling, Eastern India

“…The most-studied blood genetic markers by IEF are serum transferrin (Tf), group-specific component (Gc) and red cell phosphoglucomutase-locus 1 (PGM1) (Ktihnl andSpielman, 1978, 1979;Cleve et al, 1978;Constans and Viau, 1977;Constans and Cleve, 1979;Bark et al, t 976). Very limited data are available on these three polymorphisms in the populations of Asia, especially in the Indian regions.…”

Genetic Polymorphism of AHSG, FXIIIB, HP and PLG Serum Proteins in Six Jewish Groups in Israel

“…GC [34]; Germany (south): HP [35], AHSG [36], PLG [14]. PI [37], GC [38]; Spain: HP [39], AHSG [40]. PLG [25], PI and GC [41].…”