Genetic studies of terminal regions of vaccine and field isolates of capripoxviruses

Chaple, Ashwini R.; Venkatesan, Gnanavel; Kumar, Amit; Sarkar, Soumajit; Muthuchelvan, D.; Chandrasekar, S.; Biswas, Sanchay Kumar; Chand, Karam; Ramakrishnan, Muthannan Andavar

doi:10.1016/j.meegid.2019.104071

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…In these ANK genes 138,140,141.2 and 145 of capripoxvirus in Xinjiang, we found some specific signature position to distinguish GTPV and SPPV. Ashwini et al analyzed these different capripoxvirus strains in India and found that the four ANK genes (010,138,140, and 141.2) of capripoxvirus could be used as the target genes to distinguish GTPV and SPPV [10]. In contrast, these capripoxviruses are not only from Xinjiang, China but also from India, their ANK genes 138,140 and 141.2 have almost completely identical specific signatures, while these specific signatures of ANK 010 from capripoxvirus in India are found in the across-species in Xinjiang isolate strains of capripoxvirus, further reveled that ANK genes 138, 140 and 141.2 are more conserved than ANK 010, more suitable to be used as the target genes to distinguish GTPV and SPPV.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

Tong

Zhang

et al. 2020

Virol J

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Background Sheeppox and goatpox are both economically important animal diseases in which pathogens are goatpox virus (GTPV) and sheeppox virus (SPPV). They can’t cause cross-species infection between sheep and goats in general. But in recent decades, the infection of sheep by goatpox or goats by sheeppox has been reported. The literature has indicated that the occurrence of these cases has a significant and direct relationship with mutations of ankyrin genes families (ANK genes 010,138,140,141.2,145) located in two-terminal regions of capripoxvirus genomes. So it is very important to decipher these nucleotides and their coding amino acid sequences of the five genes regarded as host range and virulence factors for effective prevention and control of capripoxvirus diseases. Methods In this study, all the ankyrin genes of three goatpox virus, two sheeppox virus, and one GTPV vaccine strains from Nanjiang areas of Xinjiang province of China during 2010–2011 were collected, amplified, cloned and sequenced. The sequence of every ankyrin genes has been compared with not only sequences from six viruses but also all sequences from three species of capripoxvirus genus from Gene bank, and every ANK gene’s mutated nucleotides and amino acids have been screened, and the relationship of genetic evolution among different virus strains has been analyzed, as well as the domain architecture of these genes was forecasted and analyzed. Results The six capripoxvirus strains can be well-distinguished GTPV and SPPV based on five ANK genes’ sequence identicalness except for GTPV-SS strain, which showed higher identicalness with SPPV. The ANK gene sequence of the GTPV-SS strain was 100% identical with SPPV-M1 (ANK138,140,145) and SPPV-M2 (ANK138,145), respectively. Phylogenetically, these six capripoxvirus strains were also grouped into the same cluster of India reference strains in lineages and showed extreme identical conservative or variable regions with India capripoxvirus isolates by sequence alignment. Moreover, for the functional domains, these ANK genes of capripoxvirus except for ANK gene 145, are identical in size, and ANK genes 145 of SPPV are usually 100 bp (approximately 30 aa) longer than those of GTPV and eventually form a PRANC domain at C-terminus. Conclusions The isolated strain of GTPV-SS may be a cross-species infection or the collected material was contaminated, and the inferred Capripox outbreak in Xinjiang in 2010 can be introduced from India. ANK genes 138,140,141.2 and 145 of capripoxvirus can be used as the target genes to identify GTPV and SPPV. Moreover, the four ANK genes determining the host range are more significant than the ANK gene 010. These ANK genes play combining roles for their function.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

Tong

Zhang

et al. 2020

Virol J

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“…We also want to clarify why the results found are similar in our paper [ 1 ] and [ 2 ]. Firstly, the two papers employed similar methods to investigate the same genes (138, 140, 141.2) of capripoxvirus strains from their respectively different regions: our 6 strains were obtained from Xinjiang, China, while those analyzed in [ 2 ] were from India.…”

Section: Correction To: Virology Journal (2020) 17:133 101186/s12985-020-01407-wsupporting

confidence: 53%

“…Following the original article [ 1 ], it has been raised that tables 5, 6, and 7 in this paper bear many similarities to the tables from [ 2 ] (cited as reference 10 in [ 1 ]). We want to clarify this point in this correction.…”

Section: Correction To: Virology Journal (2020) 17:133 101186/s12985-020-01407-wmentioning

confidence: 97%

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Correction to: Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

Tong

Zhang

et al. 2021

Virol J

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The complete genome sequence of Indian sheeppox vaccine virus and comparative analysis with other capripoxviruses

Kumar

Venkatesan

Hosamani

et al. 2022

Gene

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Genetic studies of terminal regions of vaccine and field isolates of capripoxviruses

Cited by 4 publications

References 35 publications

Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

Correction to: Comparative analysis of ankyrin (ANK) genes of five capripoxviruses isolate strains from Xinjiang province in China

The complete genome sequence of Indian sheeppox vaccine virus and comparative analysis with other capripoxviruses

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