Genetic Structure of Qiangic Populations Residing in the Western Sichuan Corridor

Wang, Chuan‐Chao; Wang, Ling-Xiang; Shrestha, Rukesh; Zhang, Manfei; Huang, Xiu-Yuan; Kang, Houyang; Li, Jin; Li, Hui

doi:10.1371/journal.pone.0103772

Cited by 43 publications

(37 citation statements)

References 96 publications

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“…The estimated coalescent ages of the predominant lineages in ST populations provide an upper bound for their divergence/contact from other groups. MSY haplogroup O2a2b1a1-Page23, equivalent to O-M117, which was previously reported to be abundant in TB groups in southwestern China and in Han Chinese (Wang et al, 2014), was dated to around ∼2.41 kya in this study. However, this MSY lineage also occurs in HM, TK, and AA populations, reflecting recent shared ancestry and/or contact (Fig.…”

Section: Discussionsupporting

confidence: 49%

“…Although an MSY lineage (O-M122*) was proposed to be characteristic of all modern ST populations (Su et al, 2000), subsequent studies have found further differentiation, e.g. haplogroup O2a1c-002611, which is at high frequency in Han Chinese but found at very low frequencies in Tibeto-Burman populations (Wang et al, 2013, 2014; Yan et al, 2011, 2014; Yao et al, 2017). Also, autosomal STR genotypes differentiate Tibetan and Lolo-Burmese speaking groups (Li et al, 2015; Yao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand

Kutanan

Shoocongdej

Srikummool

et al. 2020

Preprint

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The Hmong-Mien (HM) and Sino-Tibetan (ST) speaking groups are known as hill tribes in Thailand; they were the subject of the first studies to show an impact of patrilocality vs. matrilocality on patterns of mitochondrial (mt) DNA vs. male-specific portion of the Y chromosome (MSY) variation. However, HM and ST groups have not been studied in as much detail; here we report and analyze 234 partial MSY sequences (∼2.3 mB) and 416 complete mtDNA sequences from 14 populations that, when combined with our previous published data, provides the largest dataset yet for the hill tribes. We find a striking difference between Hmong and IuMien (Mien-speaking) groups: the Hmong are genetically different from both the IuMien and all other Thai groups, whereas the IuMien are genetically more similar to other linguistic groups than to the Hmong. In general, we find less of an impact of patrilocality vs. matrilocality on patterns of mtDNA vs. MSY variation than previous studies. However, there is a dramatic difference in the frequency of MSY and mtDNA lineages of Northeast Asian (NEA) origin vs. Southeast Asian (SEA) origin in HM vs. ST groups: HM groups have high frequencies of NEA MSY lineages but lower frequencies of NEA mtDNA lineages, while ST groups show the opposite. A potential explanation is that the ancestors of Thai HM groups were patrilocal, while the ancestors of Thai ST groups were matrilocal. Overall, these results attest to the impact of cultural practices on patterns of mtDNA vs. MSY variation.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand

Kutanan

Shoocongdej

Srikummool

et al. 2020

Preprint

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“…This phenomenon has been observed before and was explained by selection on deleterious mutations. 27 However, owing to the better fit of genealogical rate than mutation rate with sequence-based time estimations, 25,28 we pose our time here on genealogical rate. The coalescent time of O-F444 in the Han Chinese was 7.99 ± 1.36 kya (thousand years ago).…”

Section: Resultsmentioning

confidence: 99%

“…28 The Qiangic populations might participate in the establishing of the Sino-Tibetan populations based on recent genetic evidences. 17,18,28 Detailed characterization of O-F444 may provide a broader framework of SinoTibetan populations.…”

Section: Discussionmentioning

confidence: 99%

Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134

et al. 2015

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The human Y-chromosome haplogroup O-M134 is one of the most abundant paternal lineages in East Asian populations, comprising~13% of Han Chinese males, and also common in Kazakh, Korean, Japanese, Thai and so on. Despite its considerable prevalence, its current substructure is poorly resolved with only one downstream marker (M117) previously investigated. Here we address this deficiency by investigating some single-nucleotide polymorphisms (SNPs) previously reported being potentially associated with O-M134 based on high-throughput DNA-sequencing data. Using a panel of 1301 Chinese males we first identified 154 haplogroup O-M134 subjects. We then investigated the phylogenetic structure within this haplogroup using 10 SNPs (F444, F629, F3451, F46, F48, F209, F2887, F3386, F1739 and F152). Two major branches were identified, O-M117 and O-F444 and the latter was further divided into two main subclades, O-F629 and O-F3451, accounting for 10.84 and 0.92% of the Han Chinese, respectively. This update of O-M134 diversification permits better resolution of male lineages in population studies of East Asia.

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“…Haplogroup O3a2c1*-M134 and O3a2c1a-M117 are also characteristic lineages of Han Chinese, comprising 11.4% and 16.3%, respectively910. However, another dominant paternal lineage of Han Chinese, haplogroup O3a1c-002611, is found at very low frequencies in Tibeto-Burman populations, suggesting this lineage might not have participated in the formation of Tibeto-Burman populations691011. Sex-biased admixture has also been observed during the formation of Tibeto-Burman populations.…”

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confidence: 99%

Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci

Yao

Wang

et al. 2017

Sci Rep

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The origin and diversification of Sino-Tibetan speaking populations have been long-standing hot debates. However, the limited genetic information of Tibetan populations keeps this topic far from clear. In the present study, we genotyped 15 forensic autosomal short tandem repeats (STRs) from 803 unrelated Tibetan individuals from Gansu Province (635 from Gannan and 168 from Tianzhu) in northwest China. We combined these data with published dataset to infer a detailed population affinities and genetic substructure of Sino-Tibetan populations. Our results revealed Tibetan populations in Gannan and Tianzhu are genetically very similar with Tibetans from other regions. The Tibetans in Tianzhu have received more genetic influence from surrounding lowland populations. The genetic structure of Sino-Tibetan populations was strongly correlated with linguistic affiliations. Although the among-population variances are relatively small, the genetic components for Tibetan, Lolo-Burmese, and Han Chinese were quite distinctive, especially for the Deng, Nu, and Derung of Lolo-Burmese. Han Chinese but not Tibetans are suggested to share substantial genetic component with southern natives, such as Tai-Kadai and Hmong-Mien speaking populations, and with other lowland East Asian populations, which implies there might be extensive gene flow between those lowland groups and Han Chinese after Han Chinese were separated from Tibetans. The dataset generated in present study is also valuable for forensic identification and paternity tests in China.

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Genetic Structure of Qiangic Populations Residing in the Western Sichuan Corridor

Cited by 43 publications

References 96 publications

Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand

Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand

Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134

Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci

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