Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1          (BoDV-1) distributed in cattle in Hokkaido

Sukmak, Manakorn; Okamoto, Minoru; Ando, Tatsuya; Hagiwara, Kaoru

doi:10.1292/jvms.21-0155

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…The present review mainly focuses on two species of bornaviruses that have been detected during the course of human diseases, namely BoDV‐1 and VSBV‐1. Although BoDV‐1 and VSBV‐1 infections are mainly reported in Germany, Austria, Liechtenstein and Switzerland, growing evidence suggests that other countries, including the UK, France and Japan, are also probable endemic areas 5,13,14 …”

Section: Bornavirus Infectionmentioning

confidence: 99%

“…Although BoDV-1 and VSBV-1 infections are mainly reported in Germany, Austria, Liechtenstein and Switzerland, growing evidence suggests that other countries, including the UK, France and Japan, are also probable endemic areas. 5,13,14 Therefore, it is possible that there are undetected human cases of BoDV-1 and VSBV-1 infections in these areas.…”

Section: Bornavirus Infec Tionmentioning

confidence: 99%

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Bornavirus infection in human diseases and its molecular neuropathology

Honda

2022

Clinical & Exp Neuroim

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Bornavirus has received attention as a potential pathogen involved in human psychiatric disorders for several decades. However, the hypothesis that bornavirus infection might be involved in the pathogenesis of psychiatric disorders is not well demonstrated and remains controversial. Recently, bornavirus infection has regained attention through a series of reports on confirmed cases of fatal encephalitis. [1][2][3][4][5] The present review summarizes the basic information on bornaviruses, as well as data on bornavirus infection detected during the course of human diseases. Then, the possible molecular neuropathology of bornavirus infection is discussed, with the

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Section: Bornavirus Infectionmentioning

confidence: 99%

Section: Bornavirus Infec Tionmentioning

confidence: 99%

Bornavirus infection in human diseases and its molecular neuropathology

Honda

2022

Clinical & Exp Neuroim

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Nonsuppurative Encephalitis with Detection of a Neurotropic Astrovirus Gene in a Cow

HARADA,

MOGI,

TAKANASHI

et al. 2023

J.Jpn.Vet.Med.Assoc.

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Inducing the Localization of HSP70 to Lipid Rafts by Borna Disease Virus 1 Promotes Its Invasion and Host Cells Apoptosis

Lei,

Yang,

et al. 2023

Preprint

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The Borna disease virus 1 (BoDV-1) is an emerging zoonotic virus causing severe and mostly fatal encephalitis in humans. Increasing evidence of human infections by BoDV-1 has highlighted the importance of antiviral drugs against BoDV-1. However, the process of BoDV-1 infection and its pathogenic mechanism remain elusive and there are few drugs targeting BoDV-1 infection. Our previous research suggests that BoDV-1 infects cells through lipid-related pathways. Heat shock protein 70 (HSP70) in lipid rafts (LR) has been identified to participate in various viral infections. In this study, we reported that the LR-HSP70-Caspase-3 axis engages BoDV-1 invasion and host cell apoptosis. Mechanistically, the LR inhibitor, Methyl-β-cyclodextrin (MβCD), interferes the localization HSP70 to LR and prevents BoDV-1 entry without reducing cell viability.Furthermore, we confirmed that the HSP70 is recruited into LR after BoDV-1 invasion by HSP70 knockdown and overexpression assays. And the migration of HSP70 to LR weakened the interaction between HSP70 and Caspase-3, which reducing the chaperone protective ability of HSP70 to Caspase-3, increasing the intracellular active Caspase-3 and promoting host cell apoptosis. Importantly, the MβCD treatment can effectively alleviate the symptoms and pathological changes in a model of BoDV-1 encephalitis, suggesting a significant antiviral effect in vivo. Our report reveals the process of BoDV-1 invasion and the mechanisms by which MβCD inhibits the infection, offering potential guidance for the development in the targeted treatment of BoDV-1 infection.

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Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido

Cited by 3 publications

References 44 publications

Bornavirus infection in human diseases and its molecular neuropathology

Bornavirus infection in human diseases and its molecular neuropathology

Nonsuppurative Encephalitis with Detection of a Neurotropic Astrovirus Gene in a Cow

Inducing the Localization of HSP70 to Lipid Rafts by Borna Disease Virus 1 Promotes Its Invasion and Host Cells Apoptosis

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