Genetic specificity to 6-n-propylthiouracil and its association to dental caries: A Comparative study

Vandal, Vidya B; Noorani, Hina; Shivaprakash, P K; Walikar, Basavaraj N.

doi:10.4103/0970-4388.199233

Cited by 3 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patients ranged from 12 to 42 years-old, which was similar to the range to previous studies on the association of the PROP sensitivity test and dental caries. 32 , 33 , 34 , 35 Most patients were recruited into the study after wearing fixed appliances for 2 to 9 months. This duration is long enough to observe changes related to dental caries development.…”

Section: Discussionmentioning

confidence: 99%

Bitter Taste Perception and Dental Biofilm Cariogenicity in Orthodontics

Luengthamchat

Koontongkaew

Utispan

2022

International Dental Journal

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Bitter Taste Perception and Dental Biofilm Cariogenicity in Orthodontics

Luengthamchat

Koontongkaew

Utispan

2022

International Dental Journal

View full text Add to dashboard Cite

“…51 As the non-taster phenotype and genotype are also associated with reduced sensitivity to sweet taste and liking sweets, 43,52 numerous phenotype taste tests have also been conducted, relating the non-taster status of PROP to dental decay and dental caries. [53][54][55][56][57][58][59][60][61][62][63][64][65][66] Generally, studies have found that PROP non-tasters were at higher risk of decayed, missing, and filled surfaces and caries experience compared to tasters. Medium tasters were also at higher risk compared to supertasters.…”

Section: Oral Healthmentioning

confidence: 99%

Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare

Mao¹,

Cheng²,

Li³

et al. 2023

PGPM

View full text Add to dashboard Cite

Bitter taste receptors (T2Rs) consist of 25 functional receptors that can be found in various types of cells throughout the human body with responses ranging from detecting bitter taste to suppressing pathogen-induced inflammation upon activation. Numerous studies have observed clinical associations with genetic or phenotypic variants in bitter taste receptors, most notably that of the receptor isoform T2R38. With genetic variants playing a role in the response of the body to bacterial quorum-sensing molecules, bacterial metabolites, medicinal agonists and nutrients, we examine how T2R polymorphisms, expression levels and bitter taste perception can lead to varying clinical associations. From these genetic and phenotypic differences, healthcare management can potentially be individualized through appropriately administering drugs with bitter masking to increase compliance; optimizing nutritional strategies and diets; avoiding the use of T2R agonists if this pathway is already activated from bacterial infections; adjusting drug regimens based on differing prognoses; or adjusting drug regimens based on T2R expression levels in the target cell type and bodily region.

show abstract

Correlation of Mother and Child‘s Taste Perception and their Caries Experience

Abhiram

Sankar

Sridevi

et al. 2019

Contemporary Clinical Dentistry

View full text Add to dashboard Cite

Aim and Background: Nowadays, clinical assessment of caries susceptibility is evaluated by the individuals taste perception. As food habits of the child are mostly influenced by the parents (mothers), it would be beneficial to assess the relation between mother and child's taste status and their caries experience to predict the caries susceptibility of the child. Methodology: A convenience sample of 310 mother–child dyads of both the sexes were selected. After obtaining the data on the taste preferences, dietary habits, and oral hygiene practices, caries experience of both the mother and child were recorded using the DMFT and defs indices, followed by the taste assessment using 6-n propylthiouracil (PROP) tester strips. Results: Irrespective of the taste status, the majority of the mother and child dyads showed preference to sweet foods. A statistically significant relationship between taste status and caries experience was noticed among mothers and children individually. However, there was no significant association between mother and child taste status. Whereas, a weak-positive correlation is observed between the mother and child's caries experience. The children of supertaster mothers have relatively less caries experience compared to children of moderate and nontaster mothers, which was not statistically significant. Conclusion: Mother's taste perception or caries experience may not always be a risk predictor for their child's caries experience, but the PROP tester strips were very effective in predicting the caries risk of an individual.

show abstract

Genetic specificity to 6-n-propylthiouracil and its association to dental caries: A Comparative study

Abstract: Dental caries is multi-factorial. No significant correlation between susceptibility of mother and child to genetic sensitivity exists, and genetic sensitivity is not the only criteria for severity.

Cited by 3 publications

References 1 publication

Bitter Taste Perception and Dental Biofilm Cariogenicity in Orthodontics

Bitter Taste Perception and Dental Biofilm Cariogenicity in Orthodontics

Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare

Correlation of Mother and Child‘s Taste Perception and their Caries Experience

Contact Info

Product

Resources

About