Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study

Bezerra, Flávia Fioruci; Normando, Paula; Fonseca, Ana Carolina Proença da; Zembrzuski, Verônica Marques; Campos, Mário; Acero, Pedro Hernán Cabello; Faerstein, Eduardo

doi:10.1590/0102-311x00287820

Cited by 3 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In spite of the small amount of supplemental vitamin D used in our study (200 IU/day), we cannot rule out the possibility that vitamin D per se (or as adjuvant) had some effect on changes in adipose tissue. In fact, several epidemiological studies have reported an association between low vitamin D status and higher measures of fat deposition (Bezerra et al, 2022; Lehtinen‐Jacks et al, 2016; Rafiq et al, 2019); potential explanations include sequestration and storage of vitamin D by adipose tissue and less exposure to sunlight in individuals with obesity (Vimaleswaran et al, 2013). However, experimental data rise evidence of a causal relationship in the opposite direction, suggesting that interventions with supplemental vitamin D have the potential to contribute to decrease fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

Calcium plus vitamin D supplementation during pregnancy reduces postpartum fat mass in adolescents: A randomized trial

Rached,

Diogenes,

Donangelo

et al. 2023

American J Hum Biol

Self Cite

View full text Add to dashboard Cite

BackgroundPregnancy during adolescence may increase the risk of overweight/obesity. There is evidence that increasing calcium intake, alone or vitamin D‐combined, may favor loss of weight and/or fat mass.ObjectivesWe hypothesized that calcium supplementation during pregnancy reduces excessive fat accumulation during postpartum period. We aimed to investigate the effect of calcium plus vitamin D supplementation during pregnancy on body composition measurements throughout 1 year postpartum in Brazilian adolescents with habitually low calcium intake (~600 mg/day).MethodsAdolescents (14–19 years) were randomly assigned to receive a daily supplement (600 mg of calcium plus 200 UI of cholecalciferol, n = 30) or a placebo (n = 26) from 26 weeks of gestation until parturition. Body composition was determined at 5, 20, and 56 weeks postpartum by dual‐energy x‐ray absorptiometry. The effects of intervention group, time point, as well as their interaction were assessed using repeated measures mixed‐effects models.ResultsIn the adjusted analysis, those supplemented showed lower total body mass [mean difference = −3.32 kg; confidence interval (CI) 95% −6.12 to −0.52 kg], trunk (−1.25 kg; CI 95% −2.34 to −0.15 kg), android (−0.29 kg; CI 95% −0.53 to −0.04 kg) and subcutaneous (−0.23 kg; CI 95% −0.43 to −0.03 kg) fat masses. In the supplemented group, BMI and postpartum weight retention significantly decreased from 5 to 20 weeks (−0.90 kg/m2 and −1.76 kg, respectively; p < .05). At 56 weeks, BMI was still lower (−1.22 kg/m2; p < .05) than 5 weeks.ConclusionsOur findings suggest that increasing calcium intake through supplementation in combination with vitamin D contributes to a more pronounced reduction in total body mass overtime, mostly as a consequence of fat mass reductions in central body regions. This trial was registered at clinicaltrials.gov as NCT01732328.

show abstract

Section: Discussionmentioning

confidence: 99%

Calcium plus vitamin D supplementation during pregnancy reduces postpartum fat mass in adolescents: A randomized trial

Rached,

Diogenes,

Donangelo

et al. 2023

American J Hum Biol

Self Cite

View full text Add to dashboard Cite

show abstract

Association of Serum 25-Hydroxyvitamin D and Vitamin D Intake with the Prevalence of Metabolic Syndrome in Korean Adults: 2013–2014 Korea National Health and Nutrition Examination Survey

Yoon

Min

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

Vitamin D deficiency is prevalent in Korea and an insufficient vitamin D status increases the risk of various chronic diseases including metabolic syndrome (MetS). We examined the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels, dietary vitamin D intake, and MetS. The 2013–2014 Korea National Health and Nutrition Examination Survey’s (KNHANES) included participants (n = 4.541; 1145 men; 1368 women) who were aged ≥19. In men, higher serum 25(OH)D levels were correlated with significantly increased protein intake (p = 0.032) and saturated fatty acid intake (p = 0.006), but significantly decreased fat intake (p = 0.027), monounsaturated fatty acid intake (p = 0.005), and polyunsaturated fatty acid intake (p = 0.003), and significantly decreased serum triglycerides levels (p = 0.002), whereas women had no association with any dietary intake or biochemical markers. Furthermore, our study found a significant negative correlation between abdominal obesity (OR, 0.970; CI, 0.946, 0.994) and hypertriglyceridemia (OR, 0.974; CI, 0.950, 0.998) and serum 25(OH)D levels in men, as well as a significant decrease in hypertriglyceridemia (OR, 0.980; CI, 0.961, 0.999) with vitamin D intake. However, women had a significantly negative correlation between serum LDL cholesterol (β, −1.751; p = 0.018) and vitamin D intake. By increasing the vitamin D intake and serum 25(OH)D levels, Korean adults could reduce their risk of MetS-related factors.

show abstract

Vitamin D-associated genetic variants in the Brazilian population: Investigating potential instruments for Mendelian randomization

De Souza Silverio,

Bonilla

2024

biomedica

View full text Add to dashboard Cite

Introduction. Vitamin D is required for bone and mineral metabolism and participates in the regulation of the immune response. It is also linked to several chronic diseases and conditions, usually in populations of European descent. Brazil presents a high prevalence of vitamin D deficiency and insufficiency despite the widespread availability of sunlight in the country. Thus, it is important to investigate the role of vitamin D as a risk factor for disease and to establish causal relationships between vitamin D levels and health-related outcomes in the Brazilian population.Objective. To examine genetic variants identified as determinants of serum vitamin D in genome-wide association studies of European populations and check whether the same associations are present in Brazil. If so, these single nucleotide polymorphisms (SNPs) could be developed locally as proxies to use in genetically informed causal inference methods, such as Mendelian randomization.Materials and methods. We extracted SNPs associated with vitamin D from the genomewide association studies catalog. We did a literature search to select papers ascertaining these variants and vitamin D concentrations in Brazil.Results. GC was the gene with the strongest association with vitamin D levels, in agreement with existing findings in European populations. However, VDR was themost investigated gene, regardless of its non-existing association with vitamin D in the genomewide association studies.Conclusions. More research is needed to validate sound proxies for vitamin D levels in Brazil, for example, prioritizing GC rather than VDR.

show abstract

Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study

Cited by 3 publications

References 51 publications

Calcium plus vitamin D supplementation during pregnancy reduces postpartum fat mass in adolescents: A randomized trial

Calcium plus vitamin D supplementation during pregnancy reduces postpartum fat mass in adolescents: A randomized trial

Association of Serum 25-Hydroxyvitamin D and Vitamin D Intake with the Prevalence of Metabolic Syndrome in Korean Adults: 2013–2014 Korea National Health and Nutrition Examination Survey

Vitamin D-associated genetic variants in the Brazilian population: Investigating potential instruments for Mendelian randomization

Contact Info

Product

Resources

About