Genetic selection and folate intake during pregnancy

Muñoz-Morán, E; Dieguez-Lucena, JL; Fernández-Arcás, Nieves; Peran-Mesa, S; Reyes‐Engel, Armando

doi:10.1016/s0140-6736(05)79761-0

Cited by 89 publications

(54 citation statements)

References 3 publications

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“…The Mediterranean diet, rich in folates, may also influence in the genotype difference between the north and south of Europe [53] . Low levels of vitamin B12 and/or folates in association with a homo or heterozygous MTHFR gene mutation can induce hyperhomocysteinemia; namely, this would occur as a result of an interaction between a genetic defect and the nutritional status [6,11] .…”

Section: Discussionmentioning

confidence: 99%

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain

Creus

Deulofeu

Peñarrubia

et al. 2013

Clinical Chemistry and Laboratory Medicine

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Background : Hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) gene mutation have been postulated as a possible cause of recurrent miscarriage (RM). There is a wide variation in the prevalence of MTHFR polymorphisms and homocysteine (Hcy) plasma levels among populations around the world. The present study was undertaken to investigate the possible association between hyperhomocysteinemia and its causative genetic or acquired factors and RM in Catalonia, a Mediterranean region in Spain. Methods : Sixty consecutive patients with ≥ 3 unexplained RM and 30 healthy control women having at least one child but no previous miscarriage were included. Plasma Hcy levels, MTHFR gene mutation, red blood cell (RBC) folate and vitamin B12 serum levels were measured in all subjects. Results : No significant differences were observed neither in plasma Hcy levels, RBC folate and vitamin B12 serum levels nor in the prevalence of homozygous and heterozygous MTHFR gene mutation between the two groups studied. Conclusions: In the present study RM is not associated with hyperhomocysteinemia, and/or the MTHFR gene mutation.

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Section: Discussionmentioning

confidence: 99%

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain

Creus

Deulofeu

Peñarrubia

et al. 2013

Clinical Chemistry and Laboratory Medicine

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“…Even among other Indian populations, the frequency of the T/T genotype was lower than 3% [39,40]. It has been found that the MTHFR T/T genotype in women was associated with recurrent early pregnancy loss [55] and that the prevalence of the T/T genotype was increased following supplementation of pregnant women with multivitamins [56]. Compared to Europeans, Indians consumed significantly less B vitamin supplements [57].…”

Section: Discussionmentioning

confidence: 99%

The Allele Frequencies of Three Polymorphisms in Genes Involved in Homocysteine Metabolism in a Group of Unrelated Healthy Singaporeans

Chen

2010

Disease Markers

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Abstract. The cystathionine β-synthase (CBS) 844ins68 polymorphism, methionine synthase (MS) A2756G SNP, and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T SNP are associated with homocysteine (Hcy) level in humans. Elevated Hcy level is considered a risk factor for atherosclerotic diseases among Asian populations. Therefore, the three polymorphisms may vary the risk for developing such diseases in Singaporeans. In this study, the three polymorphisms were determined in a group of unrelated healthy Singaporeans (273 Chinese, 127 Indians, and 156 Malays). Regarding allele frequencies, Indians had the highest frequencies of the CBS insertion allele (2.0%) and the MS 2756G allele (26.4%), while Chinese had the highest MTHFR 677T allele frequency (27.5%). In addition, the MTHFR 677T allele was found significantly lower in Chinese males than in their female counterparts. As the CBS insertion allele was suggested to be associated with lower Hcy level, whereas the MS 2756G allele and the MTHFR T/T genotype were related to higher Hcy level, the MS A/G or G/G genotype and the MTHFR T/T genotype were considered double genetic risk factors for elevated Hcy level. The frequency of such double genetic risk was 0.7% (4 subjects) in the total population consisting of 3 Chinese (1.1%) and 1 Malays (0.6%). No MTHFR T/T genotype was found in Indians. Such results suggested that Chinese could have higher Hcy levels than Malays while the situation for Indians was complicated. Since human Hcy levels are also affected by environmental factors, further studies are required to better evaluate the association between these three polymorphisms and Hcy levels and/or disease susceptibilities in Singaporeans.

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“…Compatible with this hypothesis, mandatory use of folic acid during pregnancy has been reported to increase the prevalence of 677T homozygosity in a Spanish population. 14 …”

mentioning

confidence: 99%

Reply to ‘MTHFR C677T and A1298C polymorphisms and mutated sequences occurring in cis’

et al. 2002

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Genetic selection and folate intake during pregnancy

Cited by 89 publications

References 3 publications

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain

The Allele Frequencies of Three Polymorphisms in Genes Involved in Homocysteine Metabolism in a Group of Unrelated Healthy Singaporeans

Reply to ‘MTHFR C677T and A1298C polymorphisms and mutated sequences occurring in cis’

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