Genetic screens identify multiple negative regulators that additively restrict recruitment of the SWI/SNF chromatin remodeler to theHOpromoter inSaccharomyces cerevisiae
Abstract:Activation of the Saccharomyces cerevisiae HO promoter is highly regulated, requiring the ordered recruitment of activators and coactivators and allowing production of only a few transcripts in mother cells within a short cell cycle window. We conducted genetic screens to identify the negative regulators of HO expression necessary to limit HO transcription. Known repressors of HO (Ash1 and Rpd3) were identified, as well as several additional chromatin-associated factors including the Hda1 histone deacetylase, … Show more
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