Abstract:Sterol regulatory element binding proteins (SREBPs) are membrane‐bound transcription factors that control lipid homeostasis in mammalian cells. Sterols regulate the activation of SREBP by inhibiting ER‐Golgi transport of SREBP and proteolysis in the Golgi. While much is known about the mechanisms of sterol‐dependent ER retention, less is known about regulation of the nuclear form of SREBP. To identify novel regulators of nuclear SREBP, we designed a genetic selection scheme in Schizosaccharomyces pombe that re… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.