Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Zhang, Yuemiao; Zhou, Hong

doi:10.2215/cjn.04370420

Cited by 30 publications

(36 citation statements)

References 10 publications

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“…Diabetic patients have a higher risk of developing chronic kidney disease, which can eventually lead to kidney failure. The situation is worse in diabetic COVID-19 patients, because SARS-CoV-2 is likely to target the kidney through an angiotensin-converting enzyme 2-dependent pathway, leading to renal impairment and death [30]. Our logistic regression model showed a positive correlation between fasting blood glucose levels and increased risk of COVID-19 death, with adjustment for other risk factors including age, gender, smoking status, and other comorbidities.…”

Section: Discussionmentioning

confidence: 73%

Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait

Alshukry¹,

Abbas²,

Ali³

et al. 2020

Preprint

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Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in 2019 and rapidly turned into a global pandemic, resulting in what is now known as Coronavirus Disease 2019 (COVID-19). COVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome. Methods: In this single-center, retrospective study of 417 consecutive COVID-19 patients in Kuwait, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients. Results: COVID-19 patients with diabetes had a higher prevalence of comorbidities, such as hypertension, higher levels of inflammatory markers, lower estimated glomerular filtration rate, and a higher incidence of complications. All of these factors could lead to more severe outcomes and higher mortality than non-diabetic COVID-19 patients. Conclusion: Diabetes could be a major contributor to COVID-19 worsening outcomes.

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Section: Discussionmentioning

confidence: 73%

Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait

Alshukry¹,

Abbas²,

Ali³

et al. 2020

Preprint

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“…In kidney, ACE2 is restrictedly expressed in tubules, suggesting tubular injury as the main renal consequence of kidney involvement of COVID-19 patients. 25 This has been validated in a recent study 26 by the observation of diffuse proximal tubule injury by light microscopy, but lack of vasculitis, interstitial inflammation or hemorrhage. Electron microscopic examination detected coronavirus-like particles with distinctive spikes in the tubular epithelium and podocytes.…”

Section: Genetic Insights Into Covid-19mentioning

confidence: 78%

The COVID-19 Pandemic from a Human Genetic Perspective

et al. 2020

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The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted a large portion of the world population. From a virus genetic perspective, a recent study described what genomic data revealed about the origin and emergence of SARS-CoV-2, proposing stronger action against illegal wildlife trade. In the current “big data” era, an increasing number of large-scale, multidimensional omics data sets were publicly available. Herein, we review how human genetics tells us about the transmission, pathogenesis, susceptibility, severity, and drug prioritization of COVID-19. We further drafted a genetic roadmap of COVID-19, which was also expected to be applicable to other viruses with known receptors. Our review provides insights into the way of understanding a pandemic from a human genetic perspective.

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“…Its expression was mostly at the apical surface of proximal tubules whereas glomeruli were negative (Figures 2B & 3). So far most of the literature and publicly available protein expression database have clearly shown high expression of ACE2 protein in human kidney tissues 8,22 . High expression of ACE2 in the kidney is believed to contribute to SARS-CoV-2 virus pathogenesis and disease severity 22 .…”

Section: Resultsmentioning

confidence: 99%

“…So far most of the literature and publicly available protein expression database have clearly shown high expression of ACE2 protein in human kidney tissues 8,22 . High expression of ACE2 in the kidney is believed to contribute to SARS-CoV-2 virus pathogenesis and disease severity 22 . Detection of kidney injuries in tissues of COVID-19 patients' post-mortem tissues further supports the importance of considering kidney 1 0 function-related issues for COVID-19 treatment and management 23 .…”

Section: Resultsmentioning

confidence: 99%

Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies

Suresh

Parida

Minz

et al. 2020

Preprint

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AbstractRecently, the Syrian golden hamster (Mesocricetus auratus) has been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals and the unavailability of reagents like antibodies against this species hampers optimal use of these models. The major objective of our current study was to analyze the tissue-specific expression pattern of angiotensin□converting enzyme 2 (ACE2), a proven functional receptor for SARS-CoV-2 in different organs of the hamster. We have adapted immunoblot analysis, immunohistochemistry, and immunofluorescence analysis techniques to evaluate the ACE2 expression pattern in different tissues of the Syrian golden hamster. We found that kidney, small intestine, esophagus, tongue, brain, and liver express ACE2. Epithelium of proximal tubules of kidney and surface epithelium of ileum expresses a very high amount of this protein. Surprisingly, analysis of stained tissue sections for ACE2 showed no detectable expression of ACE2 in the lung or tracheal epithelial cells. Similarly, all parts of the large intestine (caecum, colon, and rectum) were negative for ACE2 expression. Together, our findings corroborate some of the earlier reports related to ACE2 expression pattern in human tissues and also contradicts some others. We believe that the findings of this study will enable the appropriate use of the Syrian golden hamster to carryout SARS-CoV-2 related studies.

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Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Cited by 30 publications

References 10 publications

Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait

Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait

The COVID-19 Pandemic from a Human Genetic Perspective

Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies

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