Genetic Risk of First Degree Relatives of Coeliac Patients

Limongelli, M; Esposito, O.; Marano, C; Sacchetti, L; Tinto, Nadia; Gennarelli, D; Troncone, Riccardo; Greco, Laura

doi:10.1097/00005176-200505000-00163

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CD1

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2006

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“…Presence of the ␣-chain DQA1*05 and ␤-chain DQB1*02 alleles confers the primary increased risk of CD, but the risk for the disease is greater according to the number of DQB1*02 molecules. 16 The most likely mechanisms to explain the association with HLA class II genes is that the DQ molecule binds to gliadin peptide fragment(s) to present it to T-cells. Functional studies have shown presentation of only a subset of gliadin peptides by the non-disease-associated DQ2.2 (DQA1*0201, DQB1*0202) molecule alone and very efficient presentation by DQ2.5 for most epitopes.…”

Section: CDmentioning

confidence: 99%