Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study

Li, Zheng; Xia, Yi; Feng, Li Na; Chen, Jie Rong; Li, Hong Min; Cui, Jing; Cai, Qing Qing; Sim, Kar Seng; Nairismägi, Maarja Liisa; Laurensia, Yurike; Meah, Wee Yang; Liu, Wen Sheng; Guo, Yun; Chen, Li Zhen; Feng, Qi Sheng; Pang, Chi Pui; Chen, Li Jia; Chew, Soo Hong; Ebstein, Richard P.; Foo, Jia Nee; Li, Jianjun; Ha, Jeslin Chian Hung; Khoo, Lay Poh; Chin, Suk Teng; Zeng, Yi Xin; Aung, Tin; Chowbay, Balram; Diong, Colin Phipps; Zhang, Fen; Liu, Yan Hui; Tang, Tiffany; Tao, Miriam; Quek, Richard; Farid, Mohamad; Tan, Soo Yong; Teh, Bin Tean; Ng, Siok Bian; Chng, Wee Joo; Ong, Choon Kiat; Okada, Yukinori; Raychaudhuri, Soumya; Lim, Soon Thye; Tan, Wen; Peng, Rou Jun; Khor, Chiea‐Chuen; Bei, Jin Xin

doi:10.1016/s1470-2045(16)30148-6

Cited by 85 publications

(66 citation statements)

References 57 publications

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“…Among the sporadic NKTLs with available tissue for IHC ( n = 14), two displayed weak-cytoplasmic staining for FAM160A1, while the rest were negative. Examination of mutation frequencies in sporadic NKTL cases, derived from Singapore ( n = 33) and Chinese cohorts ( n = 189) in a previously published dataset 3 , did not reveal any FAM160A1 c.2827C > T variants. Furthermore, a preliminary analysis of our in-house clinical dataset of sporadic NKTL suggests that higher expression of FAM160A1 did not lead to differences in survival outcomes (data not shown).…”

Section: Introductionmentioning

confidence: 79%

“…Recently, some progress has been made in uncovering the molecular pathogenesis of NKTL. In a genome-wide association study, strong correlations between HLA-DPB1 single-nucleotide polymorphisms and NKTL susceptibility were discovered, implicating altered antigen processing and presentation to CD4-positive T-lymphocytes in this Epstein-Barr virus (EBV)-associated malignancy 3 . Next generation sequencing also revealed recurrent somatic mutations such as TP53 , JAK3 , STAT3 and DDX3X in NKTL 4,5 .…”

Section: Introductionmentioning

confidence: 99%

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Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma

Chan

Cheng

et al. 2018

Blood Cancer Journal

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma

Chan

Cheng

et al. 2018

Blood Cancer Journal

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“…CD30 has numerous biological functions, including cell cycle arrest, apoptosis, and activation of the prosurvival transcription factor of activated B cells. It is preferentially expressed in activated B cells but is also expressed in T cells and NK cells . .…”

Section: Discussionmentioning

confidence: 99%

CD30‐positive cutaneous extranodal natural killer/T‐cell lymphoma: clinicopathological features and survival outcomes

et al. 2018

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Background The prognostic value of CD30 expression in cutaneous extranodal natural killer/T‐cell lymphoma is controversial. Methods Clinicopathological features, survival outcomes, and prognostic implications of CD30 were retrospectively analyzed in 55 patients with cutaneous extranodal natural killer/T‐cell lymphoma. We classified patients into (i) primary cutaneous extranodal natural killer/T‐cell lymphoma and (ii) cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease depending on the primary tumor site. Results CD30+ cutaneous extranodal natural killer/T‐cell lymphoma was more common in patients with cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease than in those with primary cutaneous disease. CD30+ cases were more likely to present nodular lesions or cellulitis‐like swelling than CD30− cases. Histologically, CD30+ cutaneous extranodal natural killer/T‐cell lymphoma predominantly comprised large tumor cells compared with CD30− cases. However, the clinical morphology and tumor cell size were not associated with survival outcomes. CD30 expression was associated with better survival outcomes in patients with cutaneous extranodal natural killer/T‐cell lymphoma secondary to nasal disease. Conclusion CD30+ cutaneous extranodal natural killer/T‐cell lymphoma presented peculiar clinicopathological features and had more favorable disease course in patients with cutaneous dissemination from nasal disease.

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“…A recent genome-wide association study (GWAS) [24] showed that “oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and this association was considerably stronger in HPV-positive cancers.” What is more intriguing is that HLA again appears to play an important and consistent role in several other virus-related cancers, such as NPC [25], extra-nodal natural killer T-cell lymphoma [26], EBV-positive Hodgkin’s lymphoma [27], and chronic hepatitis B-associated hepatocellular carcinoma [28]. …”

Section: Hpv-positive Opcmentioning

confidence: 99%

The most important questions in cancer research and clinical oncology

Wee

Poh

2017

Chin J Cancer

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Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)—(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein–Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries. (d) Examining the association between HPV-positive OPC and human leukocyte antigen (HLA). (3) For non-smoking East Asian female lung adenocarcinoma—(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts. (b) Examining the association between female lung adenocarcinoma and HPV. (c) Examining the associations of lung adenocarcinoma with immune modulating factors. (4) For triple-negative breast carcinoma (TNBC) in East Asians—(a) Examining the association between TNBC and HPV. (b) Examining the unique epidemiological characteristics of patients with TNBC. A summary “epidemiological” model tying some of these findings together.

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Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study

Cited by 85 publications

References 57 publications

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma

CD30‐positive cutaneous extranodal natural killer/T‐cell lymphoma: clinicopathological features and survival outcomes

The most important questions in cancer research and clinical oncology

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