Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries

Paré, Guillaume; Neupane, Binod; Eskandarian, Sasha; Harris, Eva; Halstead, Scott B.; Gresh, Lionel; Kuan, Guillermina; Balmaseda, Ángel; Villar, Luis; Rojas, Elsa Marina; Osorio, Jorge E.; Anh, Đặng Đức; Silva, Aruna Dharshan De; Premawansa, Sunil; Premawansa, Gayani; Wijewickrama, Ananda; Lorenzana, Ivette; Parham, Leda; Rodríguez, Cynthia; Fernández‐Salas, Ildefonso; Sánchez‐Casas, Rosa; Díaz-González, Esteban E.; Aye, Khin Saw; May, Win Lai; Thein, M; Bucardo, Filemón; Reyes, Yaoska; Blandón, Patricia; Hirayama, Kenji; Weiss, Lan; Singh, Pardeep; Newton, Jennifer; Loeb, Mark

doi:10.1016/j.ebiom.2019.11.045

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…Analysis between clinical outcomes and predisposing genetic factors is quite challenging. Nevertheless, a study has evaluated multiple genetic variants that confer clinically prominent risk for disease progression, namely a study conducted by Pare et al 79 More than one-third of the prognostic factors have high heterogeneity while others were moderate to high. However, in sensitivity analysis and subgroup analysis, the effect sizes are quite similar and give consistent results with evidence of lowered heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

Sandinirwan

Muslim

Leo

et al. 2023

Preprint

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Background: The ingenuity to predict the progression to severe dengue is crucial in managing dengue patients. The previous meta-analysis has been performed on adults, and none has been performed specifically on children. We conducted a systematic review and meta-analysis to determine the clinical manifestations and laboratory parameters associated with the progression to severe dengue according to WHO criteria. Methods: We focused on searching six medical databases for studies published from Jan 1, 2000, to Dec 31, 2020. The meta-analysis used random-effects or fixed-effects models to estimate pooled effect sizes. We also assessed the heterogeneity and publication bias. This study was registered with PROSPERO, CRD42021224439. Results: We included 49 of papers in the systematic review, and we encased the final selected 39 papers comprising 23 potential predictors in the meta-analyses. Among 23 factors studied, seven clinical manifestations demonstrated association with disease progression in children, including neurological signs, gastrointestinal bleeding, clinical fluid accumulation, hepatomegaly, vomiting, abdominal pain, and petechiae. Six laboratory parameters are associated during the early days of illness, including elevated hematocrit, elevated aspartate aminotransferase [AST], elevated alanine aminotransferase [ALT], low platelet count, low albumin levels, and elevated activated partial thromboplastin time. Dengue virus serotype 2 (DENV-2) and secondary infections were also associated with severe disease progression. Conclusion: This finding supports the use of the warning signs described in the WHO 2009 guidelines. In addition, monitoring serum albumin, AST/ALT levels, identifying infecting dengue serotypes, and immunological status could improve the risk prediction of disease progression. Keywords: children, dengue, risk prediction, severity, warning sign.

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Section: Discussionmentioning

confidence: 99%

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

Sandinirwan

Muslim

Leo

et al. 2023

Preprint

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“…Hematologic parameters such as D-dimer have also been proposed for predicting dengue severity [ 18 , 19 ]. Genetic susceptibility for severe dengue has also been suggested [ 20 , 21 ]. However, these parameters require highly complex laboratory testing and may not be applicable in general hospital settings.…”

Section: Discussionmentioning

confidence: 99%

Serum Cortisol as a Biomarker of Severe Dengue

Bongsebandhu-phubhakdi

Supornsilchai

Aroonparkmongkol

et al. 2023

TropicalMed

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Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as the biomarker to predict the severity of dengue infection. This prospective study was conducted in Thailand during 2018. Serum cortisol and other laboratory tests were collected at four time points: day 1 at hospital admission, day 3, day of defervescence (DFV) (4–7 days post-fever onset), and day of discharge (DC). The study recruited 265 patients (median age (IQR) 17 (13, 27.5)). Approximately 10% presented severe dengue infection. Serum cortisol levels were highest on the day of admission and day 3. The best cut-off value of serum cortisol level for predicting severe dengue was 18.2 mcg/dL with an AUC of 0.62 (95% CI, 0.51, 0.74). The sensitivity, specificity, PPV and NPV were 65.4, 62.3, 16 and 94%, respectively. When we combined serum cortisol with persistent vomiting and day of fever, the AUC increased to 0.76. In summary, serum cortisol at day of admission was likely to be associated with dengue severity. Further studies may focus on the possibility of using serum cortisol as one of the biomarkers for dengue severity.

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“…Additionally, AB blood group has been shown to be a risk factor for DHF/DSS [208]. Other studies outline specific genetic risks for dengue severity based on genome-wide association studies, including analyses for multiple ancestries [209].…”

Section: African Ancestry and Protection From Severe Dengue: Genetics...mentioning

confidence: 99%

Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry

Gainor

Harris

LaBeaud

2022

Viruses

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Dengue is a re-emerging neglected disease of major public health importance. This review highlights important considerations for dengue disease in Africa, including epidemiology and underestimation of disease burden in African countries, issues with malaria misdiagnosis and co-infections, and potential evidence of genetic protection from severe dengue disease in populations of African descent. The findings indicate that dengue virus prevalence in African countries and populations may be more widespread than reported data suggests, and that the Aedes mosquito vectors appear to be increasing in dissemination and number. Changes in climate, population, and plastic pollution are expected to worsen the dengue situation in Africa. Dengue misdiagnosis is also a problem in Africa, especially due to the typical non-specific clinical presentation of dengue leading to misdiagnosis as malaria. Finally, research suggests that a protective genetic component against severe dengue exists in African descent populations, but further studies should be conducted to strengthen this association in various populations, taking into consideration socioeconomic factors that may contribute to these findings. The main takeaway is that Africa should not be overlooked when it comes to dengue, and more attention and resources should be devoted to this disease in Africa.

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Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries

Cited by 16 publications

References 28 publications

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

Serum Cortisol as a Biomarker of Severe Dengue

Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry

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