Genetic risk factors for renal failure among North Indian ESRD patients

Tripathi, Gaurav; Sharma, Raj Kumar; Baburaj, Vinod Pandirikkal; Sankhwar, Satya Narayan; Jafar, Tabrez; Agrawal, Suraksha

doi:10.1016/j.clinbiochem.2008.01.009

Cited by 37 publications

(34 citation statements)

References 25 publications

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“…The A allele of the Ϫ866G3 A variant was also associated with reduced risk of coronary heart disease in men with type 2 diabetes mellitus in a 6-yr prospective study (18). The deletion allele of the insertion/deletion polymorphism in the 3Ј region of UCP2 was related to ESRD in Indian subjects (19). We have now shown that the Ϫ866G3 A polymorphism of UCP2 was significantly associated with the prevalence of CKD, with the A allele representing a risk factor for this condition, although the underlying molecular mechanism remains elucidated.…”

Section: Discussionmentioning

confidence: 97%

Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

Yoshida¹,

Kato²,

Fujimaki³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition have remained uncharacterized. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals.Design, setting, participants, & measurements: The study population comprised 5217 Japanese individuals (2955 men, 2262 women), including 778 subjects (480 men, 298 women) with CKD [estimated GFR (eGFR), <50 ml min ؊1 1.73 m ؊2 ] and 4439

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Section: Discussionmentioning

confidence: 97%

Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

Yoshida¹,

Kato²,

Fujimaki³

et al. 2009

Clinical Journal of the American Society of Nephrology

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“…9 Several genetic studies have investigated the relationship between UCP2 gene polymorphism and susceptibility for the development of renal damage in humans. 10,11 Di Castro et al 12 found that UCP2 is a critical protein to prevent oxidative stress damage in renal mesangial cells in the context of hypertension. However, the role and mechanisms of UCP2 in tubular cell injury caused by hyperglycemia remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of uncoupling protein-2 by genipin exacerbates diabetes-induced kidney proximal tubular cells apoptosis

Chen

Tang

et al. 2014

Renal Failure

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Renal tubular epithelial cell injury is a major pathological event that contributes to the development of diabetic kidney disease (DKD). Uncoupling protein-2 (UCP2), a mitochondrial membrane protein, has been reported to participate in the regulation of reactive oxygen species (ROS) generation, which contributes to tubular cell apoptosis induced by hyperglycemia. In this study, we found that genipin, a UCP2 inhibitor, dramatically boosted oxidative stress, attenuated antioxidative capacity, and exacerbated cell apoptosis accompanied with caspase-3 activation in rat renal proximal tubular cells (NRK-52E) incubated with high glucose. The present study results suggest that manipulation of UCP2 could be important in the prevention of oxidative stress damage in renal tubular epithelial cells induced by hyperglycemia in vitro.

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“…A trend was seen that DD polymorphism was present in more number of cases then controls. Tripathi et al 16,17 in their series of work on genetic polymorphisms, among ESRD patients, evaluated the genetic biomarkers related to post-dialysis patients and compared these biomarkers with healthy control subjects. In their study, D allele frequency was 50.5% and I allele was 49.5% among ESRD patients.…”

Section: -15mentioning

confidence: 99%

“…But, in our study, all the CKD patients were hypertensive. Tripathi et al 16,17 have demonstrated that ACE-DD genotype may be a potential risk factor for development of chronic kidney disease. But, our study showed that subjects having DD genotype were at 1.42 times higher risk for the progression of chronic kidney disease as compared with II genotype, but it was not found statistically significant.…”

Section: -15mentioning

confidence: 99%

Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?

et al. 2016

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Background: Hypertension is one of the important contributing factors linked with both causation and development of kidney disease. It is a multifactorial, polygenic, and complex disorder due to interaction of several risk genes with environmental factors. The present study was aimed to explore genetic polymorphism in ACE-1 gene as a risk factor for CKD among hypertensive patients. Methods: Three hundred patients were enrolled in the study. Ninety were hypertensive patients with CKD taken as cases, whereas 210 hypertensive patients without CKD were taken as controls. Demographic data including age, sex, Body mass index (BMI), and other risk factors were also recorded. DNA was extracted from blood by salting out method. Genotyping of ACE gene was done by PCR technique. All the statistical analysis was done by using Epi Info and SPSS version 16 software (SPSS Inc., Chicago, IL). Results: Mean age was higher in the control group (p < 0.05). Variables among two groups were compared out of which age, BMI, hemoglobin (Hb) was found to be statistically significant whereas other variables like systolic blood pressure, triglyceride and low-density lipoprotein were not. Blood urea and serum creatinine levels were statistically significant in the two genotypes (p < 0.05). Total and HDL cholesterol were statistically significant for DD genotype of ACE gene (OR ¼ 1.42, 95% CI ¼ 0.72-2.81). Similarly, the risk for CKD among hypertensive patients was also associated with D allele of ACE gene (OR ¼ 1.25, 95% CI ¼ 0.86-1.79). Conclusion: It is concluded that ACE-DD genotype may be a risk factor for the causation and development of chronic kidney failure among hypertensive patients.

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Genetic risk factors for renal failure among North Indian ESRD patients

Cited by 37 publications

References 25 publications

Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

Downregulation of uncoupling protein-2 by genipin exacerbates diabetes-induced kidney proximal tubular cells apoptosis

Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?

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